Moderate Cosmetic Ingredient

Tripeptide-32

INCI: TRIPEPTIDE-32

CAS Number
1185583-20-3
Function
Skin conditioning (CLOCK/PER1 gene activation for circadian rhythm synchronization, DNA repair, oxidative stress defense)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No FDA classification or restriction. Not reviewed by CIR (CIR covers Tripeptide-1 but not Tripeptide-32). Falls under general cosmetic ingredient framework. MoCRA compliance required.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Tripeptide-32 (CAS 1185583-20-3) is permitted in the EU as a skin conditioning agent with no concentration limits, and permitted in the US under the general cosmetic ingredient framework with MoCRA compliance required; safety assessment relies on read-across from structurally similar tripeptides and TTC approach at trace use levels.

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Concern Level: Moderate

Regulatory Flags

data-gap proprietary-data no-cir-review no-sccs-opinion no-peer-reviewed-safety-data read-across-required

Frequently Asked Questions

Is Tripeptide-32 safe in cosmetics?

Tripeptide-32 (CAS 1185583-20-3) is permitted in the EU as a skin conditioning agent with no concentration limits, and permitted in the US under the general cosmetic ingredient framework with MoCRA compliance required; safety assessment relies on read-across from structurally similar tripeptides and TTC approach at trace use levels. The EU classifies Tripeptide-32 as "permitted". Safety rating: MODERATE.

Is Tripeptide-32 allowed in the EU?

Tripeptide-32 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Tripeptide-32 do in cosmetics?

Tripeptide-32 functions as: Skin conditioning (CLOCK/PER1 gene activation for circadian rhythm synchronization, DNA repair, oxidative stress defense). It is classified as a cosmetic ingredient in our database. CAS number: 1185583-20-3.

What is the Margin of Safety for Tripeptide-32?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Tripeptide-32 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

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Palmitoyl Oligopeptide
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Oligopeptide-34
Moderate
Oligopeptide-20
Good
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