Is Tris(N-Hydroxyethyl) Hexahydrotriazine safe in cosmetics?
Tris(N-Hydroxyethyl) Hexahydrotriazine has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted.
Poor
Cosmetic Ingredient
Tris(N-Hydroxyethyl) Hexahydrotriazine
Also known as: Hexahydro-1,3,5-tris(hydroxyethyl)-s- triazine, Grotan BK, Hexahydro-1,3,5-tri(2-hydroxyethyl)-s-triazine, s-Triazine-1,3,5(2H,4H,6H)-triethanol, N,N',N''-Tris(2-hydroxyethyl)hexahydro-s-triazine (+15 more)
INCI: TRIS(N-HYDROXYETHYL) HEXAHYDROTRIAZINE
Tris(N-Hydroxyethyl) Hexahydrotriazine (CAS 4719-04-4) is a cosmetic cosmetic ingredient functioning as Fragrance functional, skin conditioning, skin protecting. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 4719-04-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Tris(N-Hydroxyethyl) Hexahydrotriazine is classified GHS Danger (H302, H317, H319, H330, H372, H331, H370, H401) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance functional, skin conditioning, skin protecting
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-[3,5-bis(2-hydroxyethyl)-1,3,5-triazinan-1-yl]ethanol
InChIKey
HUHGPYXAVBJSJV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted in cosmetics; primarily used as industrial biocide/preservative
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tris(N-Hydroxyethyl) Hexahydrotriazine.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Warning
Pictograms
Harmful / Irritant
Hazard Class and Category
Acute Tox. 4 *; Skin Sens. 1
Hazard Statements
- H302 Harmful if swallowed
- H317 May cause an allergic skin reaction
Specific Concentration Limits / M-factors
Skin Sens. 1; H317: C ≥ 0.1%
Inserted via ATP: CLP00
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10,000 - 100,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Humectant
No specific technical function
Preservative
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Tris(N-Hydroxyethyl) Hexahydrotriazine.
Regulatory Flags
fragrance-component
Known Synonyms
Hexahydro-1,3,5-tris(hydroxyethyl)-s- triazine
Grotan BK
Hexahydro-1,3,5-tri(2-hydroxyethyl)-s-triazine
s-Triazine-1,3,5(2H,4H,6H)-triethanol
N,N',N''-Tris(2-hydroxyethyl)hexahydro-s-triazine
N,N',N''-Tris(beta-hydroxyethyl)hexahydro-s-triazine
Actane
Acticide GR
Bactraclean
Bestcide 1087T
Bioban GK
Busan 1060
Busan 1506
Cobate C
Dodigen NJ
ETA 75
KM 200
KM 200 (alcohol)
Mergal 165
Nipacide BK
Chemical Function
Preservative
Humectant
Softener and conditioner
Biocide
No specific technical function
Regulatory Lists
active_ingredient; Europe; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3561636
Frequently Asked Questions
Is Tris(N-Hydroxyethyl) Hexahydrotriazine allowed in the EU?
Tris(N-Hydroxyethyl) Hexahydrotriazine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tris(N-Hydroxyethyl) Hexahydrotriazine do in cosmetics?
Tris(N-Hydroxyethyl) Hexahydrotriazine functions as: Fragrance functional, skin conditioning, skin protecting. It is classified as a cosmetic ingredient in our database. CAS number: 4719-04-4.
Is Tris(N-Hydroxyethyl) Hexahydrotriazine used outside cosmetics?
Tris(N-Hydroxyethyl) Hexahydrotriazine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Tris(N-Hydroxyethyl) Hexahydrotriazine have different safety status in cosmetics vs industrial chemicals?
Tris(N-Hydroxyethyl) Hexahydrotriazine is classified GHS Danger (H302, H317, H319, H330, H372, H331, H370, H401) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Tris(N-Hydroxyethyl) Hexahydrotriazine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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