4-Nitroguaiacol

INCI: 4-NITROGUAIACOL

CAS Number
3251-56-7
Function
Fragrance / masking agent
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Not specifically restricted by FDA; no CIR safety assessment published

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Nitro-aromatic compound with structural alert for mutagenicity; insufficient cosmetic safety data and no published CIR assessment; nitro group introduces additional safety concerns beyond parent guaiacol.

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Concern Level: High

Regulatory Flags

fragrance-component eu_banned_cosmetics eu_cosing_listed

Frequently Asked Questions

Is 4-Nitroguaiacol safe in cosmetics?

Nitro-aromatic compound with structural alert for mutagenicity; insufficient cosmetic safety data and no published CIR assessment; nitro group introduces additional safety concerns beyond parent guaiacol. The EU classifies 4-Nitroguaiacol as "prohibited". Safety rating: POOR.

Is 4-Nitroguaiacol allowed in the EU?

4-Nitroguaiacol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does 4-Nitroguaiacol do in cosmetics?

4-Nitroguaiacol functions as: Fragrance / masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 3251-56-7.

What is the Margin of Safety for 4-Nitroguaiacol?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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