Is 4-Nitroguaiacol safe in cosmetics?
4-Nitroguaiacol has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted.
Poor
Cosmetic Ingredient
4-Nitroguaiacol
Also known as: 4-06-00-05627, BRN 1868796, EINECS 221-839-0, Guaiacol, 4-nitro-, 4-Hydroxy-3-methoxynitrobenzene (+6 more)
INCI: 4-NITROGUAIACOL
4-Nitroguaiacol (CAS 3251-56-7) is a cosmetic cosmetic ingredient functioning as Fragrance / masking agent. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 3251-56-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance / masking agent
Safety Rating
POOR
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Not specifically restricted by FDA; no CIR safety assessment published
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 4-Nitroguaiacol.
Calculate MoS for your specific formulation with the MoS Calculator.
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1251
(EC) 2009/1223
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1251
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Prohibited (GNRAS)
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (2)
EU Banned in Cosmetics
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for 4-Nitroguaiacol.
Regulatory Flags
fragrance-component
eu_banned_cosmetics
eu_cosing_listed
Known Synonyms
4-06-00-05627
BRN 1868796
EINECS 221-839-0
Guaiacol, 4-nitro-
4-Hydroxy-3-methoxynitrobenzene
o-Methoxy-p-nitrophenol
3-Nitro-6-hydroxyanisole
NSC 26149
Phenol, o-methoxy-p-nitro-
UNII-41ITO2N6UT
2-Methoxy-4-nitrophenol
Chemical Function
Dye
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
banned; Europe; Personal care
Frequently Asked Questions
Is 4-Nitroguaiacol allowed in the EU?
4-Nitroguaiacol EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does 4-Nitroguaiacol do in cosmetics?
4-Nitroguaiacol functions as: Fragrance / masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 3251-56-7.
Compliance Tools
Check 4-Nitroguaiacol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
1,2,4-Benzenetriacetate
Poor
Similar safety
Hair dye precursor (triacetyl ester o...
1,2,4-Trihydroxybenzene
Poor
Similar safety
Hair colorant (auto-oxidative dye)
1,3-Bis-(Isocyanatomethyl) Cyclohexane
Poor
Similar safety
Monomer / cross-linking agent used in...
1,4-Butanediol
Poor
Similar safety
Solvent, humectant, viscosity control...
1,6-Hexamethylene Diisocyanate (HDI)
Poor
Similar safety
Monomer and crosslinker in polymer sy...
1,6-Hexanediamine
Poor
Similar safety
Industrial chemical (nylon monomer); ...
4-Nitro-M-Phenylenediamine
Poor
Browse nearby
Hair dye (direct/semi-permanent)
4-Nitro-M-Phenylenediamine Sulfate
Poor
Browse nearby
Hair dye (salt form)
4-Nitro-O-Phenylenediamine
Moderate
Browse nearby
Hair colorant used in both oxidative ...
Is 4-Nitroguaiacol in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for 4-Nitroguaiacol in your formulation.