Good Active Ingredient

Acetyl Tetrapeptide-3

INCI: ACETYL TETRAPEPTIDE-3

CAS Number
827306-88-7
Function
Signal peptide; ECM protein synthesis stimulant; follicle anchoring; hair-growth active
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted cosmetic active. Key component of Capixyl proprietary complex at suggested 5% use level.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
negligible
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Acetyl Tetrapeptide-3 is the peptide component of the Capixyl complex that stimulates synthesis of ECM proteins anchoring the hair follicle, reducing perifollicular inflammation and strengthening follicle structure. Clinical studies demonstrate significant efficacy against androgenetic alopecia with no adverse effects at 5% use level.

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Concern Level: Low

Regulatory Flags

hair-growth-active signal-peptide ecm-stimulant capixyl-component rcp-study-evidenced fphl-clinical-data

Frequently Asked Questions

Is Acetyl Tetrapeptide-3 safe in cosmetics?

Acetyl Tetrapeptide-3 is the peptide component of the Capixyl complex that stimulates synthesis of ECM proteins anchoring the hair follicle, reducing perifollicular inflammation and strengthening follicle structure. Clinical studies demonstrate significant efficacy against androgenetic alopecia with no adverse effects at 5% use level. The EU classifies Acetyl Tetrapeptide-3 as "permitted". Safety rating: GOOD.

Is Acetyl Tetrapeptide-3 allowed in the EU?

Acetyl Tetrapeptide-3 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Acetyl Tetrapeptide-3 do in cosmetics?

Acetyl Tetrapeptide-3 functions as: Signal peptide; ECM protein synthesis stimulant; follicle anchoring; hair-growth active. It is classified as a Active Ingredient in our database. CAS number: 827306-88-7.

What is the Margin of Safety for Acetyl Tetrapeptide-3?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Acetyl Tetrapeptide-3 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
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