Is Acetyl Tetrapeptide-3 safe in cosmetics?
Acetyl Tetrapeptide-3 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Acetyl Tetrapeptide-3
INCI: ACETYL TETRAPEPTIDE-3
Acetyl Tetrapeptide-3 (CAS 827306-88-7) is a cosmetic active ingredient functioning as Signal peptide; ECM protein synthesis stimulant; follicle anchoring;. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 827306-88-7 →
Auto-generated CPSR Part A draft with source citations
Function
Signal peptide; ECM protein synthesis stimulant; follicle anchoring; hair-growth active
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S)-2-[[(2S)-2-[[2-[[(2S)-2-acetamido-6-aminohexanoyl]amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanamide
InChIKey
RRJOMESUBQAYOA-BZSNNMDCSA-N
SMILES
CC(=O)NC(CCCCN)C(=O)NCC(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted cosmetic active. Key component of Capixyl proprietary complex at suggested 5% use level.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetyl Tetrapeptide-3.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
peptide
{"cas_number": "827025-41-8", "trade_name": "Capixyl component", "peptide_sequence_amino_acids": "Ac-Gly-His-Lys-Tyr", "peptide_length_residues": "4", "molecular_weight_daltons": "551.6", "peptide_class": "signal/enzyme_inhibitor", "mechanism_of_action": "Reduces 5-alpha reductase (DHT), stimulates ECM proteins in hair follicle", "target_protein_or_receptor": "5-alpha-reductase inhibition", "colla…
Expert Verdict
Expert safety assessment and concern-level summary for Acetyl Tetrapeptide-3.
Regulatory Flags
hair-growth-active
signal-peptide
ecm-stimulant
capixyl-component
rcp-study-evidenced
fphl-clinical-data
Frequently Asked Questions
Is Acetyl Tetrapeptide-3 allowed in the EU?
Acetyl Tetrapeptide-3 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetyl Tetrapeptide-3 do in cosmetics?
Acetyl Tetrapeptide-3 functions as: Signal peptide; ECM protein synthesis stimulant; follicle anchoring; hair-growth active. It is classified as a Active Ingredient in our database. CAS number: 827306-88-7.
Is Acetyl Tetrapeptide-3 used outside cosmetics?
Acetyl Tetrapeptide-3 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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ACETALDEHYDE
Moderate
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