Excellent Emollient Dermal Penetration

Caprylic/Capric Triglyceride

INCI: CAPRYLIC/CAPRIC TRIGLYCERIDE

CAS Number
65381-09-1
Function
Fractionated medium-chain triglyceride (MCT) ester composed of caprylic (C8) and capric (C10) fatty acids esterified to glycerol. Derived from coconut or palm kernel oil by fractionation. Functions as emollient, skin-conditioning agent, carrier, solvent, and lipid matrix for advanced delivery systems. Fully saturated with excellent oxidative stability. Used as carrier lipid in Solid Lipid Nanoparticle (SLN) and Nanostructured Lipid Carrier (NLC) formulations and as the lipid vehicle in phospholipid delivery systems for encapsulation of lipophilic actives.
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes FDA GRAS for food use. CIR Expert Panel confirmed very low toxicity. In vivo study (15% w/w emulsion) demonstrated increased superficial skin hydration with TEWL reduction. Used as lipid matrix in SLN and NLC nanocarrier formulations and as vehicle in phospholipid delivery systems. Palm kernel/coconut derived. No federal restrictions.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Caprylic/Capric Triglyceride, relevant to systemic exposure and MoS calculations.

Absorption %
1-4%
Penetration Level
stratum-corneum
Penetration Depth
stratum corneum
Molecular Weight
470.7 Da
Log P
8.5
Systemic Absorption
minimal
Topical Bioavailability
0.5-3%
Safety Margin Factor
low

Source: CIR

Expert Verdict

CIR Expert Panel confirmed very low toxicity; FDA GRAS for food use. Clinical in vivo evidence demonstrates skin hydration increase and TEWL reduction. Excellent oxidative stability due to fully saturated C8/C10 chains with no peroxidation concern. Functions as standard emollient carrier and as lipid matrix in advanced nanocarrier systems (SLN, NLC) and phospholipid delivery vehicles.

โš ๏ธ
Concern Level: None

Regulatory Flags

palm-derived-rspo-preferred

Frequently Asked Questions

Is Caprylic/Capric Triglyceride safe in cosmetics?

CIR Expert Panel confirmed very low toxicity; FDA GRAS for food use. Clinical in vivo evidence demonstrates skin hydration increase and TEWL reduction. Excellent oxidative stability due to fully saturated C8/C10 chains with no peroxidation concern. Functions as standard emollient carrier and as lipid matrix in advanced nanocarrier systems (SLN, NLC) and phospholipid delivery vehicles. The EU classifies Caprylic/Capric Triglyceride as "permitted". Safety rating: EXCELLENT.

Is Caprylic/Capric Triglyceride allowed in the EU?

Caprylic/Capric Triglyceride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Caprylic/Capric Triglyceride do in cosmetics?

Caprylic/Capric Triglyceride functions as: Fractionated medium-chain triglyceride (MCT) ester composed of caprylic (C8) and capric (C10) fatty acids esterified to glycerol. Derived from coconut or palm kernel oil by fractionation. Functions as emollient, skin-conditioning agent, carrier, solvent, and lipid matrix for advanced delivery systems. Fully saturated with excellent oxidative stability. Used as carrier lipid in Solid Lipid Nanoparticle (SLN) and Nanostructured Lipid Carrier (NLC) formulations and as the lipid vehicle in phospholipid delivery systems for encapsulation of lipophilic actives.. It is classified as a Emollient in our database. CAS number: 65381-09-1.

What is the Margin of Safety for Caprylic/Capric Triglyceride?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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