Also known as: α-D-galacto-β-D-Mannan, α-D-Galactopyrano-β-D-mannopyranan, Burtonite V-7-E, EINECS 232-536-8, FEMA No. 2537 (+11 more)
INCI: CYAMOPSIS TETRAGONOLOBA (GUAR) GUM
Cyamopsis Tetragonoloba (Guar) Gum (CAS 9000-30-0) is a cosmetic uv filter / sunscreen functioning as Thickening agent, stabilizer. Reported NOAEL =1000 mg/kg body weight in rat (CIR Safety Assessment); EU Regulation 1223/2009 status: restricted; 2 safety opinions reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical and food safety data.
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Margin of Safety, dermal absorption, and sensitization profile summaries for Cyamopsis Tetragonoloba (Guar) Gum.
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6 study endpoints found for Cyamopsis Tetragonoloba (Guar) Gum. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg body weight | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =1000 mg/kg body weight | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =1000 mg/kg body weight | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =1000 mg/kg body weight | oral | rat | developmental toxicity | CIR Safety Assessment |
| NOAEL | =2500 mg/kg bw/day | - | Rat | chronic/long term toxicity | EFSA |
| NOAEL | =2500 mg/kg bw/day | - | Rat | chronic/long term toxicity | EFSA |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
netration of these ingredients would be unlikely. The Panel concluded that these galactomannans are safe in the present practices of use and concentration described in this safety assessment. Keywords galactomannans, safety, cosmetics Introduction As given in the International Cosmetic Ingredient Dictio
netration of these ingredients would be unlikely. The Panel concluded that these galactomannans are safe in the present practices of use and concentration described in this safety assessment. Keywords galactomannans, safety, cosmetics Introduction As given in the International Cosmetic Ingredient Dictio
3 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =8100 mg/kg | Mouse | oral | - | ChemIDplus |
| LD50 | =7000 mg/kg | Rabbit | oral | - | ChemIDplus |
| LD50 | =6770 mg/kg | Rat | oral | - | ChemIDplus |
Preliminary editorial summary for Cyamopsis Tetragonoloba (Guar) Gum — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to Cyamopsis Tetragonoloba (Guar) Gum by CAS number or substance name.
Units vary across source rows: mg/kg body weight, mg/kg bw/day
Same-CAS public records found in pharmaceutical and food safety data.
Same-CAS rows from the pharmaceutical spoke database.
Same-CAS food additive or FDA GRAS records from the core public database.
Cyamopsis Tetragonoloba (Guar) Gum has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 6 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
Cyamopsis Tetragonoloba (Guar) Gum EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
Cyamopsis Tetragonoloba (Guar) Gum functions as: Thickening agent, stabilizer. It is classified as a UV Filter / Sunscreen in our database. CAS number: 9000-30-0.
The NOAEL (No Observed Adverse Effect Level) for Cyamopsis Tetragonoloba (Guar) Gum is =1000 mg/kg body weight based on a developmental toxicity study via oral route in rat. A total of 6 study endpoints are available. Source: CIR Safety Assessment.
Cyamopsis Tetragonoloba (Guar) Gum also appears in pharmaceutical and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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