Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Diacetyl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 540 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Critical inhalation hazard with well-documented cause of bronchiolitis obliterans from occupational exposure; NIOSH health hazard alerts issued. Must not be used in aerosolizable, sprayable, or powder cosmetics. Dermal-only applications at low concentrations carry lower risk, but absence of cosmetic-specific margin of safety is a major data gap.
Regulatory Flags
Frequently Asked Questions
Is Diacetyl safe in cosmetics?
Critical inhalation hazard with well-documented cause of bronchiolitis obliterans from occupational exposure; NIOSH health hazard alerts issued. Must not be used in aerosolizable, sprayable, or powder cosmetics. Dermal-only applications at low concentrations carry lower risk, but absence of cosmetic-specific margin of safety is a major data gap. The EU classifies Diacetyl as "prohibited". Safety rating: POOR. 2 toxicological study endpoint(s) are available in our database.
Is Diacetyl allowed in the EU?
Diacetyl EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Diacetyl do in cosmetics?
Diacetyl functions as: Masking agent, fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 431-03-8.
What is the Margin of Safety for Diacetyl?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Diacetyl?
The NOAEL (No Observed Adverse Effect Level) for Diacetyl is 540 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Is Diacetyl classified as hazardous under GHS?
Diacetyl carries a GHS signal word of "DANGER". Hazard statements: Highly flammable liquid and vapour Harmful if swallowed Toxic if inhaled Causes skin irritation Causes serious eye irritation Causes damage to respiratory system if inhaled Causes damage to respiratory system through prolonged or repeated exposure if inhaled Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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