Is Drometrizole Trisiloxane (Mexoryl XL) safe in cosmetics?
Drometrizole Trisiloxane (Mexoryl XL) has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted.
Drometrizole Trisiloxane (Mexoryl XL)
Also known as: Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]-, Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl]-, 2-(2H-Benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]phenol, 2-(2H-Benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl]phenol, OR 10154 (+1 more)
INCI: DROMETRIZOLE TRISILOXANE
Drometrizole Trisiloxane (Mexoryl XL) (CAS 155633-54-8) is a cosmetic uv filter / sunscreen functioning as UV Filter. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 155633-54-8 →
Function
UV Filter
Editorial assessment
MODERATE
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not GRAS; restricted use in sunscreen products
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Drometrizole Trisiloxane (Mexoryl XL).
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Drometrizole Trisiloxane (Mexoryl XL) based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
other
EU Allergen Listed
no
Patch Test Positive Rate
0.1%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
Source: EU SCCS
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: UV filter
Receptor targets: ERα (limited)
LOEC: 10 µM
EU status: allowed (max 15%)
weak modulator
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
No longer valid
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex VI — Permitted UV Filters
Max: 15%
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: UV Filter. Max: 15%.
SA Saudi SFDA (VI - UV Filters)
Max: 0.15.
JPKR Japan/Korea Cosmetics
Japan (Restricted): max Wash-away: 15% | Leave-on: 15% | Mucosa: Prohibited
Korea (Restricted): max 15%
BRIN Brazil/India Cosmetics
India: Permitted UV Filter · max 0.15
Additional Jurisdictional Restrictions (4)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| JP | restricted | Wash-away: 15% | Leave-on: 15% | Mucosa: Prohibited | Wash-away: 15% | Leave-on: 15% | Mucosa: Prohibited |
| CN | permitted_uv_filter | 15 | All cosmetics |
| IN | permitted_uv_filter | 15.0 | sunscreen and other cosmetic products |
| BR | permitted_uv_filter | 15 | Sunscreen products; EU max 15% |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
UV stabilizer
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Editorial summary
Preliminary editorial summary for Drometrizole Trisiloxane (Mexoryl XL) — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
eu_cosing_listed
Known Synonyms
Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]-
Phenol, 2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl]-
2-(2H-Benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]-1-disiloxanyl]propyl]phenol
2-(2H-Benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(trimethylsilyl)oxy]disiloxanyl]propyl]phenol
OR 10154
EC 422-940-4
Chemical Function
UV stabilizer
Regulatory Lists
Canada; pharmaceutical
Europe; Personal care
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Frequently Asked Questions
Is Drometrizole Trisiloxane (Mexoryl XL) allowed in the EU?
Drometrizole Trisiloxane (Mexoryl XL) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Drometrizole Trisiloxane (Mexoryl XL) do in cosmetics?
Drometrizole Trisiloxane (Mexoryl XL) functions as: UV Filter. It is classified as a UV Filter / Sunscreen in our database. CAS number: 155633-54-8.
Compliance Tools
Check Drometrizole Trisiloxane (Mexoryl XL) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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