Excellent Antioxidant

Epigallocatechin Gallate

INCI: EPIGALLOCATECHIN GALLATE

CAS Number
989-51-5
Function
Antioxidant; green tea catechin polyphenol; HAT/SET free radical scavenger; metal chelator; anti-inflammatory; inhibits UV-induced immunosuppression
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No FDA restrictions. Green tea extract generally regarded as safe at cosmetic use concentrations. CIR has addressed green tea-derived ingredients broadly.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
Natural catechin from Camellia sinensis. No genotoxicity at cosmetic concentrations. No significant safety concerns at 0.5โ€“5% extract concentrations. Extensive human dietary safety data from tea consumption.
Dermal Absorption
Hydrophilic polyphenol; struggles to bypass hydrophobic SC without delivery enhancement. Ethosomes and binary ethosomes significantly improve catechin penetration. Metal chelation provides additional preventive antioxidant mechanism.
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Most potent and well-studied green tea catechin with triple mechanism: HAT/SET radical scavenging, metal chelation, and UV immunoprotection. Typical use 0.5โ€“5% as green tea extract. Key challenge: hydrophilic nature requires delivery enhancement such as ethosomes or liposomes for meaningful stratum corneum penetration. Strong anti-aging and anti-pollution profile.

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Concern Level: None

Regulatory Flags

antioxidant polyphenol green-tea hat-set-mechanism metal-chelator hydrophilic encapsulation-recommended uv-immunoprotection anti-pollution unstable delivery-challenge

Frequently Asked Questions

Is Epigallocatechin Gallate safe in cosmetics?

Most potent and well-studied green tea catechin with triple mechanism: HAT/SET radical scavenging, metal chelation, and UV immunoprotection. Typical use 0.5โ€“5% as green tea extract. Key challenge: hydrophilic nature requires delivery enhancement such as ethosomes or liposomes for meaningful stratum corneum penetration. Strong anti-aging and anti-pollution profile. The EU classifies Epigallocatechin Gallate as "permitted". Safety rating: EXCELLENT.

Is Epigallocatechin Gallate allowed in the EU?

Epigallocatechin Gallate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Epigallocatechin Gallate do in cosmetics?

Epigallocatechin Gallate functions as: Antioxidant; green tea catechin polyphenol; HAT/SET free radical scavenger; metal chelator; anti-inflammatory; inhibits UV-induced immunosuppression. It is classified as a Antioxidant in our database. CAS number: 989-51-5.

What is the Margin of Safety for Epigallocatechin Gallate?

Natural catechin from Camellia sinensis. No genotoxicity at cosmetic concentrations. No significant safety concerns at 0.5โ€“5% extract concentrations. Extensive human dietary safety data from tea consumption. The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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