Glycyrrhetinic Acid

INCI: GLYCYRRHETINIC ACID

CAS Number
471-53-4
Function
Skin conditioning — anti-inflammatory, soothing agent derived from licorice
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes Permitted — no CFR restriction; CIR concluded safe in present practices of use and concentration

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Glycyrrhetinic acid is safe for topical cosmetic use with no concern in typical concentrations; related compound glycyrrhizic acid causes pseudo-aldosteronism only at high oral doses, which is not applicable to topical application.

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Concern Level: Low

Frequently Asked Questions

Is Glycyrrhetinic Acid safe in cosmetics?

Glycyrrhetinic acid is safe for topical cosmetic use with no concern in typical concentrations; related compound glycyrrhizic acid causes pseudo-aldosteronism only at high oral doses, which is not applicable to topical application. The EU classifies Glycyrrhetinic Acid as "permitted". Safety rating: EXCELLENT.

Is Glycyrrhetinic Acid allowed in the EU?

Glycyrrhetinic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Glycyrrhetinic Acid do in cosmetics?

Glycyrrhetinic Acid functions as: Skin conditioning — anti-inflammatory, soothing agent derived from licorice. It is classified as a cosmetic ingredient in our database. CAS number: 471-53-4.

What is the Margin of Safety for Glycyrrhetinic Acid?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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