Hexapeptide-2

INCI: HEXAPEPTIDE-2

CAS Number
87616-84-0
Function
Skin bleaching agent, skin conditioning agent
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes No CIR safety assessment exists for Hexapeptide-2. Falls under standard MoCRA compliance. No FDA GRAS classification applicable.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Hexapeptide-2 is an MC1-R antagonist used for skin brightening; EU-permitted but lacks SCCS opinion, CIR monograph, and published dermal absorption data, warranting caution pending full safety substantiation.

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Concern Level: Moderate

Regulatory Flags

no-sccs-opinion no-cir-monograph no-dermal-absorption-data no-sensitization-study no-mos-calculated skin-bleaching-agent active-biological-function

Frequently Asked Questions

Is Hexapeptide-2 safe in cosmetics?

Hexapeptide-2 is an MC1-R antagonist used for skin brightening; EU-permitted but lacks SCCS opinion, CIR monograph, and published dermal absorption data, warranting caution pending full safety substantiation. The EU classifies Hexapeptide-2 as "permitted". Safety rating: MODERATE.

Is Hexapeptide-2 allowed in the EU?

Hexapeptide-2 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hexapeptide-2 do in cosmetics?

Hexapeptide-2 functions as: Skin bleaching agent, skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 87616-84-0.

What is the Margin of Safety for Hexapeptide-2?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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