Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Methyl 2-Octynoate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 3.2 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| dose_tested | 3.2 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| dose_tested | 250 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| dose_tested | 250 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
Sensitization Profile
Contact sensitization data for Methyl 2-Octynoate based on clinical patch test studies and IFRA standards.
Source: ESSCA/IVDK
Expert Verdict
Good safety profile within approved limits; restricted in EU with concentration limits per Annex III.
Regulatory Flags
Frequently Asked Questions
Is Methyl 2-Octynoate safe in cosmetics?
Good safety profile within approved limits; restricted in EU with concentration limits per Annex III. The EU classifies Methyl 2-Octynoate as "restricted". Safety rating: GOOD. 6 toxicological study endpoint(s) are available in our database.
Is Methyl 2-Octynoate allowed in the EU?
Methyl 2-Octynoate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl 2-Octynoate do in cosmetics?
Methyl 2-Octynoate functions as: Fragrance. It is classified as a Fragrance in our database. CAS number: 111-12-6.
What is the Margin of Safety for Methyl 2-Octynoate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Methyl 2-Octynoate?
The NOAEL (No Observed Adverse Effect Level) for Methyl 2-Octynoate is 3.2 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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