Is Methyldibromo Glutaronitrile safe in cosmetics?
Methyldibromo Glutaronitrile has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Methyldibromo Glutaronitrile
INCI: METHYLDIBROMO GLUTARONITRILE
Methyldibromo Glutaronitrile (CAS 35691-65-7) is a cosmetic cosmetic ingredient functioning as Broad-spectrum antimicrobial preservative (bacteria, yeasts, molds). EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 35691-65-7 →
Auto-generated CPSR Part A draft with source citations
Function
Broad-spectrum antimicrobial preservative (bacteria, yeasts, molds)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-bromo-2-(bromomethyl)pentanedinitrile
InChIKey
DHVLDKHFGIVEIP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
No specific FDA restriction; CIR reaffirmed (2017) safe in rinse-off and safe at <0.025% in leave-on; US use at 0.005-0.04%
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methyldibromo Glutaronitrile.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and skin.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by ingestion.
Sensitization Profile
Contact sensitization data for Methyldibromo Glutaronitrile based on clinical patch test studies and IFRA standards.
Sensitization Rate
moderate
Allergen Class
preservative
EU Allergen Listed
no
Patch Test Positive Rate
2.0%
Cross-reactivity Group
none
Reaction Type
contact-dermatitis
Source: Banned EU; ESSCA
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Acute ToxicityHealth HazardCorrosiveEnvironmental Hazard
Hazard Class and Category
Acute Tox. 2; Acute Tox. 4; STOT RE 2; Eye Dam. 1; Skin Sens. 1A; Aquatic Chronic 2
Hazard Statements
- H330 Fatal if inhaled
- H302 Harmful if swallowed
- H373 (thyroid
- central nervous system)
- H318 Causes serious eye damage
- H317 May cause an allergic skin reaction
- H411 Toxic to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
inhalation: ATE = 0.27 mg/L dusts or mists; oral: ATE = 500.0 mg/kg bw; Skin Sens. 1A; H317: C ≥ 0.001%
Inserted via ATP: ATP23
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
99.6%
DPRA Lys %
24.2%
KeratinoSens IC50
38.66 µM
hCLAT CV75
9.9 µg/mL
LLNA EC3
0.9%
NESIL
225 µg/cm²
LLNA: Strong (1A)
GHS: 1A
Source: LLNA: Gerberick et al. (2005); DPRA: Bauch et al. 2012 [DOI:10.1016/j.yrtph.2012.05.013] | Jaworska 2011 [DOI:10.1002/jat.2869]; KS: Joint Research Centre of the European Union 2014 | Natsch et al. 2011 [DOI:10.1021/tx2003678]; hCLAT: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008] | Sakaguchi et al. 2010 [DOI:10.1016/j.tiv.2010.05.012]
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | - | - | - |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| ASEAN | permitted_preservative | 0.1% | All products (not sunscreens >0.03%) |
| KR | prohibited | - | - |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "preservative", "patch_test_frequency_pct": "2.0", "sensitization_rate": "moderate", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "Banned EU; ESSCA"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
1,2-Dibromo-2,4-Dicyanobutane | TR-555: Toxicology and Carcinogenesis Studies of 1,2-Dibromo-2,4-dicyanobutane (CASRN 35691-65-7) in F344/N Rats and B6C3F1 Mice (Dermal Studies) (2010 ) | 02/27/08 | No Evidence | No Evidence | No Evidence | No Evidence | Under the conditions of these 2-year dermal studies there was no evidence of carcinogenic activity of 1,2-dibromo-2,4-dicyanobutane in m
Source: NTP Technical Reports
ICSC Safety Card
1546
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Biocide
Preservative
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Methyldibromo Glutaronitrile.
Regulatory Flags
Allergen
Chemical Function
Preservative
Biocide
Regulatory Lists
CEDI
Indirect additives food contact (10/2018)
inert_ingredient; non_food_use; Pesticides
active_ingredient; Europe; Pesticides
Canada; pharmaceutical
Canada; pharmaceutical
consumer_product; Europe
Europe; Personal care - body hygiene - hand soap
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
active_ingredient; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3188084
Frequently Asked Questions
Is Methyldibromo Glutaronitrile allowed in the EU?
Methyldibromo Glutaronitrile EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyldibromo Glutaronitrile do in cosmetics?
Methyldibromo Glutaronitrile functions as: Broad-spectrum antimicrobial preservative (bacteria, yeasts, molds). It is classified as a cosmetic ingredient in our database. CAS number: 35691-65-7.
Is Methyldibromo Glutaronitrile used outside cosmetics?
Methyldibromo Glutaronitrile also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Methyldibromo Glutaronitrile compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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