Is METHYLENE DIPHENYL DIISOCYANATE safe in cosmetics?
METHYLENE DIPHENYL DIISOCYANATE has a safety rating of "MODERATE" in our database. EU status: restricted.
METHYLENE DIPHENYL DIISOCYANATE
Also known as: 4,4'-Methylenedi(phenyl isocyanate), 1,1'-Methylenebis [4-isocyanatobenzene], 4,4'-MDI, 4-13-00-00396, BRN 0797662 (+15 more)
METHYLENE DIPHENYL DIISOCYANATE (CAS 101-68-8) is a cosmetic cosmetic ingredient functioning as Not Reported. EU Regulation 1223/2009 status: restricted, max II/1533. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 101-68-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
METHYLENE DIPHENYL DIISOCYANATE is classified GHS Danger (H315, H317, H319, H332, H334, H335, H351, H373) in the chemicals database but is restricted in EU cosmetics at max II/1533.
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Not Reported
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1-isocyanato-4-[(4-isocyanatophenyl)methyl]benzene
InChIKey
UPMLOUAZCHDJJD-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
II/1533
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
Lachrymation. The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the lungs. This may result in impaired functions.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma. See Notes.
Routes of Exposure
The substance can be absorbed into the body by inhalation.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
19, Sup 7, 71
Evaluation Year
1998
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (5)
Carcinogen Classification
3, not classifiable as to its carcinogenicity to humans. (L135)
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
4,4'-Methylenediphenyl diisocyanate | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 19: (1979) Some Monomers, Plastics and Synthetic Elastomers, and Acrolein | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 71: (1999) Re-evaluation of Some Organic Chemicals, H
Source: International Agency for Research on Cancer (IARC)
Evidence for Carcinogenicity
Evaluation: There is inadequate evidence for the carcinogenicity of 4,4'-methylenediphenyl diisocyanate or polymeric 4,4'-methylenediphenyl diisocyanate in humans. There is limited evidence in experimental animals for the carcinogenicity of a mixture containing monomeric and polymeric 4,4'-methylenediphenyl diisocyanate. Overall evaluation: 4,4'-Methylenediphenyl diisocyanate (industrial preparati
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
0298
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Irritating /to/ eyes, nose, throat. | A skin and eye irritant. An allergic sensitizer.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Adhesion/cohesion promoter
Binder
Catalyst
Hardener
No specific technical function
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for METHYLENE DIPHENYL DIISOCYANATE.
Regulatory Flags
cosing-sourced
eu-restricted
needs-enrichment
Known Synonyms
4,4'-Methylenedi(phenyl isocyanate)
1,1'-Methylenebis [4-isocyanatobenzene]
4,4'-MDI
4-13-00-00396
BRN 0797662
Desmodur 44
Di-(4-isocyanatophenyl)methane
4,4'-Diphenylmethanediisocyante
EINECS 202-966-0
Isocyanic acid, ester with diphenylmethane
Isonate
Isonate 125M
Isonate 125 MF
Nacconate 300
NCI-C50668
para,para'-Methylenebis(phenyl isocyanate)
Rubinate 44
Difenil-metan-diisocianato
Difenylmethaan-dissocyanaat
UNII-B0LO6BBS8C
Chemical Function
Binder
Hardener
Adhesion/cohesion promoter
Regulatory Lists
banned; Europe; Personal care
Cons electronics mech appliances and machinery; Europe; nondetect
Europe; nondetect; Toys and children's products
detected; Europe; Toys and children's products
drinking_water; Europe; manufacturing; plastic_additive
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1488467
Frequently Asked Questions
Is METHYLENE DIPHENYL DIISOCYANATE allowed in the EU?
METHYLENE DIPHENYL DIISOCYANATE EU regulatory status: restricted. Maximum allowed concentration: II/1533. This is based on EU Regulation 1223/2009 and its amendments.
What does METHYLENE DIPHENYL DIISOCYANATE do in cosmetics?
METHYLENE DIPHENYL DIISOCYANATE functions as: Not Reported. It is classified as a cosmetic ingredient in our database. CAS number: 101-68-8.
Is METHYLENE DIPHENYL DIISOCYANATE used outside cosmetics?
METHYLENE DIPHENYL DIISOCYANATE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does METHYLENE DIPHENYL DIISOCYANATE have different safety status in cosmetics vs industrial chemicals?
METHYLENE DIPHENYL DIISOCYANATE is classified GHS Danger (H315, H317, H319, H332, H334, H335, H351, H373) in the chemicals database but is restricted in EU cosmetics at max II/1533.
Compliance Tools
Check METHYLENE DIPHENYL DIISOCYANATE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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