Is N-Phenyl-p-Phenylenediamine safe in cosmetics?
N-Phenyl-p-Phenylenediamine has a safety rating of "POOR" in our database. EU status: restricted. US status: permitted.
N-Phenyl-p-Phenylenediamine
INCI: N-PHENYL-P-PHENYLENEDIAMINE
N-Phenyl-p-Phenylenediamine (CAS 101-54-2 (free base); 2198-59-6 (HCl); 4698-29-7 (sulfate)) is a cosmetic cosmetic ingredient functioning as Oxidative hair dye. EU Regulation 1223/2009 status: restricted, max 0.2%. Industrial safety data is also available in the chemical safety database.
Auto-generated CPSR Part A draft with source citations
CAS Number
101-54-2 (free base); 2198-59-6 (HCl); 4698-29-7 (sulfate)
View industrial chemical safety profile →
Function
Oxidative hair dye
Safety Rating
POOR
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.2%
US US Status
permitted
US Notes
Permitted under coal tar hair dye exemption (21 USC 361(a)); CIR: safe up to 1.7% as free base; caution statement per 21 CFR 740.2
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for N-Phenyl-p-Phenylenediamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for N-Phenyl-p-Phenylenediamine based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.8%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis
Source: IVDK; NACDG; ESSCA
Additional Ingredient Properties
2 property records from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "dye", "cross_reactivity_group": "para-amino-group", "patch_test_frequency_pct": "0.8", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; NACDG; ESSCA"}
hair_dye
{"cas_number": "101-54-2", "ingredient_class": "oxidative_dye_precursor", "color_index_CI_number": "76085", "chemical_class": "para_phenylenediamine", "molecular_weight_Da": "184.24", "color_result_on_hair": "Blue-violet", "shade_range": "black", "primary_function": "precursor", "oxidative_dye_type": "primary_intermediate", "requires_developer": "yes", "developer_volume_compatibility": "10/20/30",…
Expert Verdict
Expert safety assessment and concern-level summary for N-Phenyl-p-Phenylenediamine.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to N-Phenyl-p-Phenylenediamine by CAS number or substance name.
Studies
4
Lowest NOAEL
50 mg/kg bw
Highest NOAEL
50 mg/kg bw
SCCS_vision_codex
Frequently Asked Questions
Is N-Phenyl-p-Phenylenediamine allowed in the EU?
N-Phenyl-p-Phenylenediamine EU regulatory status: restricted. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.
What does N-Phenyl-p-Phenylenediamine do in cosmetics?
N-Phenyl-p-Phenylenediamine functions as: Oxidative hair dye. It is classified as a cosmetic ingredient in our database. CAS number: 101-54-2 (free base); 2198-59-6 (HCl); 4698-29-7 (sulfate).
Compliance Tools
Check N-Phenyl-p-Phenylenediamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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