Is N-Phenyl-p-Phenylenediamine safe in cosmetics?
N-Phenyl-p-Phenylenediamine has a safety rating of "POOR" in our database. EU status: restricted. US status: permitted.
N-Phenyl-p-Phenylenediamine
INCI: N-PHENYL-P-PHENYLENEDIAMINE
N-Phenyl-p-Phenylenediamine (CAS 101-54-2 (free base); 2198-59-6 (HCl); 4698-29-7 (sulfate)) is a cosmetic cosmetic ingredient functioning as Oxidative hair dye. EU Regulation 1223/2009 status: restricted, max 0.2%. Industrial safety data is also available in the chemical safety database.
CAS Number
101-54-2 (free base); 2198-59-6 (HCl); 4698-29-7 (sulfate)
View industrial chemical safety profile →
Function
Oxidative hair dye
Editorial assessment
POOR
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.2%
US US Status
permitted
US Notes
Permitted under coal tar hair dye exemption (21 USC 361(a)); CIR: safe up to 1.7% as free base; caution statement per 21 CFR 740.2
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for N-Phenyl-p-Phenylenediamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for N-Phenyl-p-Phenylenediamine based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
dye
EU Allergen Listed
no
Patch Test Positive Rate
0.8%
Cross-reactivity Group
para-amino-group
Reaction Type
contact-dermatitis
Source: IVDK; NACDG; ESSCA
Editorial summary
Preliminary editorial summary for N-Phenyl-p-Phenylenediamine — not a computed safety verdict. See the sourced toxicological data above.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to N-Phenyl-p-Phenylenediamine by CAS number or substance name.
Studies
4
Lowest NOAEL
50 mg/kg bw
Highest NOAEL
50 mg/kg bw
SCCS Opinion
Frequently Asked Questions
Is N-Phenyl-p-Phenylenediamine allowed in the EU?
N-Phenyl-p-Phenylenediamine EU regulatory status: restricted. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.
What does N-Phenyl-p-Phenylenediamine do in cosmetics?
N-Phenyl-p-Phenylenediamine functions as: Oxidative hair dye. It is classified as a cosmetic ingredient in our database. CAS number: 101-54-2 (free base); 2198-59-6 (HCl); 4698-29-7 (sulfate).
Compliance Tools
Check N-Phenyl-p-Phenylenediamine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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