Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
9 study endpoints found for NAD+ Precursors. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 600 mg/kg bw/day | oral | rabbit | Short Term Toxicity | COSMOS_DB |
| NOAEL | 800 mg/kg bw/day | oral | guinea pig | Short Term Toxicity | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 600 mg/kg bw/day | oral | rabbit | Short Term Toxicity | COSMOS_DB |
| dose_tested | 800 mg/kg bw/day | oral | guinea pig | Short Term Toxicity | COSMOS_DB |
| NOAEL | 215 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | 12.5 mg/kg bw/day | oral | - | oral | REACH |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Expert Verdict
Niacinamide is a well-established cosmetic ingredient with a history of safe use; however, safety data specific to NAD+ precursor formulations should be reviewed.
Regulatory Flags
Frequently Asked Questions
Is NAD+ Precursors safe in cosmetics?
Niacinamide is a well-established cosmetic ingredient with a history of safe use; however, safety data specific to NAD+ precursor formulations should be reviewed. The EU classifies NAD+ Precursors as "permitted". Safety rating: GOOD. 9 toxicological study endpoint(s) are available in our database.
Is NAD+ Precursors allowed in the EU?
NAD+ Precursors EU regulatory status: permitted. Maximum allowed concentration: 5%. This is based on EU Regulation 1223/2009 and its amendments.
What does NAD+ Precursors do in cosmetics?
NAD+ Precursors functions as: Biosynthetic building blocks for nicotinamide adenine dinucleotide (NAD+), a critical coenzyme. It is classified as a Cosmetic Ingredient in our database. CAS number: 98-92-0.
What is the Margin of Safety for NAD+ Precursors?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for NAD+ Precursors?
The NOAEL (No Observed Adverse Effect Level) for NAD+ Precursors is 1000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 9 study endpoints are available. Source: COSMOS_DB.
Is NAD+ Precursors classified as hazardous under GHS?
NAD+ Precursors carries a GHS signal word of "WARNING". Hazard statements: Causes eye irritation. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Compliance Tools
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