Good Active Ingredient

Palmitoyl Tripeptide-1

INCI: PALMITOYL TRIPEPTIDE-1

CAS Number
147732-56-7
Function
Skin-conditioning agent; collagen-stimulating peptide
Safety Rating
GOOD

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR Expert Panel confirmed Tripeptide-1, Hexapeptide-12, their metal salts and fatty acyl derivatives, and Palmitoyl Tetrapeptide-7 are safe as used in cosmetics. Covered under CIR safety assessment for this ingredient class.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Palmitoyl Tripeptide-1 (Gly-His-Lys sequence; component of Matrixyl 3000) drives collagen and glycosaminoglycan synthesis via fibroblast stimulation. CIR Expert Panel confirms Tripeptide-1 and its fatty acyl derivatives safe as used in cosmetics. A 28-day clinical study on 32 volunteers showed significant reductions in wrinkle depth, volume, and number. Standalone formulations show retinoid-comparable activity without irritation. No EU or US regulatory restrictions.

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Concern Level: Low

Regulatory Flags

peptide matrikine collagen-stimulating anti-aging eye-area matrixyl

Frequently Asked Questions

Is Palmitoyl Tripeptide-1 safe in cosmetics?

Palmitoyl Tripeptide-1 (Gly-His-Lys sequence; component of Matrixyl 3000) drives collagen and glycosaminoglycan synthesis via fibroblast stimulation. CIR Expert Panel confirms Tripeptide-1 and its fatty acyl derivatives safe as used in cosmetics. A 28-day clinical study on 32 volunteers showed significant reductions in wrinkle depth, volume, and number. Standalone formulations show retinoid-comparable activity without irritation. No EU or US regulatory restrictions. The EU classifies Palmitoyl Tripeptide-1 as "permitted". Safety rating: GOOD.

Is Palmitoyl Tripeptide-1 allowed in the EU?

Palmitoyl Tripeptide-1 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Palmitoyl Tripeptide-1 do in cosmetics?

Palmitoyl Tripeptide-1 functions as: Skin-conditioning agent; collagen-stimulating peptide. It is classified as a Active Ingredient in our database. CAS number: 147732-56-7.

What is the Margin of Safety for Palmitoyl Tripeptide-1?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Palmitoyl Tripeptide-1 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

Related Ingredients

Ascophyllum Nodosum Extract
Excellent
Palmitoyl Dipeptide-6 Diaminohydroxybutyr
Moderate
Linoleic Acid
Excellent
Morus Alba Root Extract
Good
Bacillus Ferment
Good
Browse all 30,000+ ingredients →
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