Moderate Cosmetic Ingredient

SH-Oligopeptide-2

INCI: SH-OLIGOPEPTIDE-2

CAS Number
67763-96-6
Function
Skin conditioning agent, skin protecting agent, growth factor (IGF-1)
Safety Rating
MODERATE

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No specific FDA restriction on SH-Oligopeptide-2 as a cosmetic ingredient. Under MoCRA, standard product listing requirements apply. IGF-1 as a pharmaceutical active (mecasermin/Increlex) is FDA-regulated as a biologic; the cosmetic application at trace concentrations occupies a different regulatory lane. No CIR safety assessment published.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Recombinant human IGF-1 (70 amino acids, ~7.6 kDa) produced via E. coli fermentation. EU: listed in CosIng for skin conditioning and skin protecting; not in Annexes II, III, V, or VI; no SCCS opinion exists. US: no specific FDA restriction; falls under cosmetic lane under MoCRA; drug/cosmetic boundary for growth factors remains a regulatory gray zone. CIR has not published a safety assessment covering SH-Oligopeptide-2. High molecular weight (~7,600 Da) strongly predicts minimal percutaneous penetration under intact skin barrier.

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Concern Level: Moderate

Regulatory Flags

data-gap no-sccs-opinion no-cir-review no-mos-data no-absorption-data no-sensitization-data growth-factor high-molecular-weight china-market-risk drug-cosmetic-boundary recombinant-peptide cold-process-required

Frequently Asked Questions

Is SH-Oligopeptide-2 safe in cosmetics?

Recombinant human IGF-1 (70 amino acids, ~7.6 kDa) produced via E. coli fermentation. EU: listed in CosIng for skin conditioning and skin protecting; not in Annexes II, III, V, or VI; no SCCS opinion exists. US: no specific FDA restriction; falls under cosmetic lane under MoCRA; drug/cosmetic boundary for growth factors remains a regulatory gray zone. CIR has not published a safety assessment covering SH-Oligopeptide-2. High molecular weight (~7,600 Da) strongly predicts minimal percutaneous penetration under intact skin barrier. The EU classifies SH-Oligopeptide-2 as "permitted". Safety rating: MODERATE.

Is SH-Oligopeptide-2 allowed in the EU?

SH-Oligopeptide-2 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does SH-Oligopeptide-2 do in cosmetics?

SH-Oligopeptide-2 functions as: Skin conditioning agent, skin protecting agent, growth factor (IGF-1). It is classified as a cosmetic ingredient in our database. CAS number: 67763-96-6.

What is the Margin of Safety for SH-Oligopeptide-2?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check SH-Oligopeptide-2 compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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Oligopeptide-20
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Hexapeptide-2
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