Is SH-Oligopeptide-2 safe in cosmetics?
SH-Oligopeptide-2 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
SH-Oligopeptide-2
Also known as: IGF, Somatomedin C, Sulfation factor C, Insulin-like growth factor-1
INCI: SH-OLIGOPEPTIDE-2
SH-Oligopeptide-2 (CAS 67763-96-6) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent, skin protecting agent, growth factor (IGF-1). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 67763-96-6 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning agent, skin protecting agent, growth factor (IGF-1)
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restriction on SH-Oligopeptide-2 as a cosmetic ingredient. Under MoCRA, standard product listing requirements apply. IGF-1 as a pharmaceutical active (mecasermin/Increlex) is FDA-regulated as a biologic; the cosmetic application at trace concentrations occupies a different regulatory lane. No CIR safety assessment published.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for SH-Oligopeptide-2.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
peptide
{"cas_number": "116870-93-2", "trade_name": "IGF-1 / Insulin-like Growth Factor 1", "peptide_sequence_amino_acids": "Recombinant 70-amino acid protein", "peptide_length_residues": "70", "molecular_weight_daltons": "7649.0", "peptide_class": "signal", "mechanism_of_action": "Binds IGF-1 receptor, promotes cell proliferation and ECM synthesis", "target_protein_or_receptor": "IGF-1R", "biomimetic_of"…
Expert Verdict
Expert safety assessment and concern-level summary for SH-Oligopeptide-2.
Regulatory Flags
data-gap
no-sccs-opinion
no-cir-review
no-mos-data
no-absorption-data
no-sensitization-data
growth-factor
high-molecular-weight
china-market-risk
drug-cosmetic-boundary
recombinant-peptide
cold-process-required
Known Synonyms
IGF
Somatomedin C
Sulfation factor C
Insulin-like growth factor-1
Regulatory Lists
pharmaceutical; prohibited
pharmaceutical; prohibited
Frequently Asked Questions
Is SH-Oligopeptide-2 allowed in the EU?
SH-Oligopeptide-2 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does SH-Oligopeptide-2 do in cosmetics?
SH-Oligopeptide-2 functions as: Skin conditioning agent, skin protecting agent, growth factor (IGF-1). It is classified as a cosmetic ingredient in our database. CAS number: 67763-96-6.
Compliance Tools
Check SH-Oligopeptide-2 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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