Also known as: SDS, Anticerumen, Aquarex methyl, Carsonol SLS, Carsonol SLS Paste B (+14 more)
SODIUM LAURYL SULFATE (CAS 151-21-3) is a cosmetic surfactant functioning as Surfactant; foaming agent; primary cleanser. Reported NOAEL =460 mg/kg bw/day in Rat (ECHA); EU Regulation 1223/2009 status: permitted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
SODIUM LAURYL SULFATE is classified GHS Danger (H228, H302, H315, H318, H319, H332, H335, H412) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for SODIUM LAURYL SULFATE.
Calculate MoS for your specific formulation with the MoS Calculator.
1 study endpoint found for SODIUM LAURYL SULFATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =460 mg/kg bw/day | oral | Rat | subchronic | ECHA |
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Contact sensitization data for SODIUM LAURYL SULFATE based on clinical patch test studies and IFRA standards.
Source: NACDG; IVDK; ESSCA
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LOAEL | =920 mg/kg-day | Rat | oral | subchronic | ECHA |
| LOAEL | <=600 mg/kg-day | Rat | oral | short-term | ECHA |
| LOAEL | >300 mg/kg-day | Rat | oral | short-term | ECHA |
| NOAEL | >600 mg/kg-day | Rabbit | oral | - | ECHA |
| NOAEL | >=500 mg/kg-day | Rat | oral | - | ECHA |
| NOAEL | >600 mg/kg-day | Rat | oral | - | ECHA |
| NOAEL | >=430 mg/kg-day | Rat | oral | subchronic | ECHA |
| NOAEL | =460 mg/kg-day | Rat | oral | subchronic | ECHA |
| NOEL | =100 mg/kg-day | Rat | oral | short-term | ECHA |
| LOAEL | =920 mg/kg-day | Rat | oral | subchronic | ECHA |
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
Source: LLNA: Montelius et al (1994) | Gerberick et al. (2005); DPRA: Bauch et al. 2011 [DOI:10.1016/j.tiv.2011.05.030] | Natsch et al. 2013 [DOI:10.1002/jat.2868]; KS: Joint Research Centre of the European Union 2014 | Natsch et al. 2011 [DOI:10.1021/tx2003678]; hCLAT: Urbisch et al. 2015 [DOI:10.1016/j.yrtph.2014.12.008] | Sakaguchi et al. 2010 [DOI:10.1016/j.tiv.2010.05.012]; HPPT: [27] Kligman AM (1966): https://doi.org/10.1038/jid.1966.160
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6206.9 | - | - |
| OECD_DA_Human | - | 0 | - | - | Non-sensitizer |
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
weak modulator (membrane disruption)
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| AU | restricted | - | cleansers |
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Shampoo | 2–8 | 15 | CIR Safety Assessment |
| Toothpaste | 1–2 | 2 | CIR Expert Panel |
| Toothpaste (Oral) | 1–2 | 2 | CIR Expert Panel |
Preliminary editorial summary for SODIUM LAURYL SULFATE — not a computed safety verdict. See the sourced toxicological data above.
Public NOAEL study rows linked to SODIUM LAURYL SULFATE by CAS number or substance name.
Same-CAS public records found in pharmaceutical and food safety data.
Same-CAS rows from the pharmaceutical spoke database.
Same-CAS food additive or FDA GRAS records from the core public database.
SODIUM LAURYL SULFATE has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by CIR Safety Assessment.
SODIUM LAURYL SULFATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
SODIUM LAURYL SULFATE functions as: Surfactant; foaming agent; primary cleanser. It is classified as a Surfactant in our database. CAS number: 151-21-3.
The NOAEL (No Observed Adverse Effect Level) for SODIUM LAURYL SULFATE is =460 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ECHA.
SODIUM LAURYL SULFATE carries a GHS signal word of "WARNING". Hazard statements: Harmful if swallowed or in contact with skin Causes skin and eye irritation May cause respiratory irritation Toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
SODIUM LAURYL SULFATE also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
SODIUM LAURYL SULFATE is classified GHS Danger (H228, H302, H315, H318, H319, H332, H335, H412) in the chemicals database but is allowed in EU cosmetics.
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