Is Tetramethylammonium Chloride safe in cosmetics?
Tetramethylammonium Chloride has a safety rating of "POOR" in our database. EU status: permitted. US status: restricted. 1 toxicological study endpoint(s) are available in our database.
Tetramethylammonium Chloride
Also known as: methanaminium, N,N,N-trimethyl-, chloride, EINECS 200-880-8, UNII-DCQ9S88703
INCI: TETRAMETHYLAMMONIUM CHLORIDE
Tetramethylammonium Chloride (CAS 75-57-0) is a cosmetic cosmetic ingredient functioning as Viscosity controlling agent. Reported NOAEL =10 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 75-57-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Tetramethylammonium Chloride is classified GHS Danger (H300, H301, H311, H315, H319, H335, H370, H411) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Viscosity controlling agent
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
tetramethylazanium chloride
InChIKey
OKIZCWYLBDKLSU-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not specifically restricted for cosmetic use; permitted under general cosmetic ingredient provisions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetramethylammonium Chloride.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Tetramethylammonium Chloride. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract. The substance may cause effects on the central nervous system.
Routes of Exposure
The substance can be absorbed into the body by inhalation and by ingestion.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1099
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Catalyst
Stabilizing agent
Viscosity modifier
Expert Verdict
Expert safety assessment and concern-level summary for Tetramethylammonium Chloride.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Tetramethylammonium Chloride by CAS number or substance name.
Studies
1
Lowest NOAEL
10 mg/kg bw/day
Highest NOAEL
10 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
methanaminium, N,N,N-trimethyl-, chloride
EINECS 200-880-8
UNII-DCQ9S88703
Chemical Function
Viscosity modifier
Stabilizing agent
Catalyst
Regulatory Lists
fracking
fracking; water
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TETRAMETHYLAMMONIUM
ChEMBL ID
CHEMBL1209651
Frequently Asked Questions
Is Tetramethylammonium Chloride allowed in the EU?
Tetramethylammonium Chloride EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetramethylammonium Chloride do in cosmetics?
Tetramethylammonium Chloride functions as: Viscosity controlling agent. It is classified as a cosmetic ingredient in our database. CAS number: 75-57-0.
What is the NOAEL for Tetramethylammonium Chloride?
The NOAEL (No Observed Adverse Effect Level) for Tetramethylammonium Chloride is =10 mg/kg bw/day based on a subchronic study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Tetramethylammonium Chloride used outside cosmetics?
Tetramethylammonium Chloride also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Tetramethylammonium Chloride have different safety status in cosmetics vs industrial chemicals?
Tetramethylammonium Chloride is classified GHS Danger (H300, H301, H311, H315, H319, H335, H370, H411) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Tetramethylammonium Chloride compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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