Is Triheptanoin safe in cosmetics?
Triheptanoin has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 8 toxicological study endpoint(s) are available in our database.
Triheptanoin
Also known as: Propane-1,2,3-triyl triheptanoate, Heptanoic acid, 1,2,3-propanetriyl ester, Heptanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester, Heptanoin, tri-, Dermofeel TC 7 (+11 more)
INCI: TRIHEPTANOIN
Triheptanoin (CAS 620-67-7) is a cosmetic cosmetic ingredient functioning as Emollient, skin conditioning agent, occlusive, viscosity controlling agent. Reported NOAEL =10 mg/kg bw/d in rat (CIR Safety Assessment); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
Function
Emollient, skin conditioning agent, occlusive, viscosity controlling agent
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
2,3-di(heptanoyloxy)propyl heptanoate
InChIKey
PJHKBYALYHRYSK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA approved as pharmaceutical (Dojolvi/UX007) for LC-FAOD; COSMOS-approved; CIR Safe as used (2017/2018)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Triheptanoin.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Triheptanoin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =10 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =10 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =10 mg/kg bw/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =3500 mg/kg/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =3500 mg/kg/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =3500 mg/kg/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
| NOAEL | =3500 mg/kg/d | oral | rat | repeated dose toxicity | CIR Safety Assessment |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Surfactant (surface active agent)
Thickening agent
Viscosity modifier
Editorial summary
Preliminary editorial summary for Triheptanoin — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
PENETRATION_ENHANCER
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Triheptanoin by CAS number or substance name.
Studies
8
Lowest NOAEL
10
Highest NOAEL
3500
Units vary across source rows: mg/kg bw/d, mg/kg/d
CIR Safety Assessment
Known Synonyms
Propane-1,2,3-triyl triheptanoate
Heptanoic acid, 1,2,3-propanetriyl ester
Heptanoic acid, 1,1',1''-(1,2,3-propanetriyl) ester
Heptanoin, tri-
Dermofeel TC 7
Glycerol triheptanoate
Glyceryl triheptanoate
Lanol 37T
Trienanthoin
Triheptanoic glyceride
Trioenanthoin
Glycerol-triheptanoate-
propane-1,2,3-triyl trisheptanoate
trisheptanoate de propane-1,2,3-triyle
Propan-1,2,3-triyltrisheptanoat
trisheptanoato de propano-1,2,3-triilo
Chemical Function
Surfactant (surface active agent)
Softener and conditioner
Viscosity modifier
Humectant
Thickening agent
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
pharmaceutical
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
TRIHEPTANOIN
ChEMBL ID
CHEMBL4297585
Max Phase
4
Adverse Event Associations
15
Frequently Asked Questions
Is Triheptanoin allowed in the EU?
Triheptanoin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Triheptanoin do in cosmetics?
Triheptanoin functions as: Emollient, skin conditioning agent, occlusive, viscosity controlling agent. It is classified as a cosmetic ingredient in our database. CAS number: 620-67-7.
What is the NOAEL for Triheptanoin?
The NOAEL (No Observed Adverse Effect Level) for Triheptanoin is =10 mg/kg bw/d based on a repeated dose toxicity study via oral route in rat. A total of 8 study endpoints are available. Source: CIR Safety Assessment.
Is Triheptanoin used outside cosmetics?
Triheptanoin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Triheptanoin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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