Good UV Filter / Sunscreen NOAEL Data

Uvasorb HEB (Diethylhexyl Butamido Triazone)

Also known as: Bis(2-ethylhexyl) 4,4'-({6-[4-(tert-butylcarbamoyl)anilino]-1,3,5-triazine-2,4-diyl}diazanediyl)dibenzoate, 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate, Uvasorb HEB

INCI: DIETHYLHEXYL BUTAMIDO TRIAZONE

Uvasorb HEB (Diethylhexyl Butamido Triazone) (CAS 154702-15-5) is a cosmetic uv filter / sunscreen functioning as UV Filter. Reported NOAEL =500 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 154702-15-5 →

Auto-generated CPSR Part A draft with source citations
CAS Number
154702-15-5
View industrial chemical safety profile →
Function
UV Filter
Safety Rating
GOOD

Chemistry & Identifiers

EC Number
421-450-8
UNII: 2UTZ0QC864 Wikidata: Q6079473

Regulatory Status

EU EU Status permitted
US US Status permitted

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Uvasorb HEB (Diethylhexyl Butamido Triazone).

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

3 study endpoints found for Uvasorb HEB (Diethylhexyl Butamido Triazone). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =500 mg/kg bw/day oral Rat reproduction developmental ToxValDB_ECHA_IUCLID
NOAEL =831 mg/kg bw/day oral Rat subchronic ToxValDB_ECHA_IUCLID
NOAEL =963 mg/kg bw/day oral Rat subchronic ToxValDB_ECHA_IUCLID

EPA ToxValDB — Toxicity Values

10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).

Endpoint Value Species Route Duration Source
LD50 >2000 mg/kg Rat oral - ECHA IUCLID
LD50 >2000 mg/kg Rat oral - ECHA IUCLID
LD50 >2000 mg/kg Rat oral - ECHA IUCLID
NOAEL =831 mg/kg-day Rat oral subchronic ECHA IUCLID
NOAEL =963 mg/kg-day Rat oral subchronic ECHA IUCLID
NOAEL =500 mg/kg-day Rat oral - ECHA IUCLID
NOAEL >1000 mg/kg-day Rat oral - ECHA IUCLID
NOAEL >1000 mg/kg-day Rat oral - ECHA IUCLID
LD50 >2000 mg/kg Rat dermal acute ECHA IUCLID
LD50 >2000 mg/kg Rat oral - ECHA IUCLID

Endocrine Disruptor Evidence (Expanded)

Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.

Cosmetic-Specific Mechanism
Category: UV filter
Receptor targets: TR (weak)
LOEC: 10 µM
EU status: allowed (max 10%)

modulator

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No

EU CosIng Annex Listing

European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.

Annex VI — Permitted UV Filters
Max: 10%

Expanded Jurisdictional Detail

Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.

KR Korea MFDS Annex 2 (Restricted)
Category: UV Filter. Max: 10%.
SA Saudi SFDA (VI - UV Filters)
Max: 0.1.
BRIN Brazil/India Cosmetics
India: Permitted UV Filter · max 0.1
Additional Jurisdictional Restrictions (4)
Jurisdiction Status Max % Product Type
CN permitted_uv_filter 20 All cosmetics
BR permitted_uv_filter 10 Sunscreen products
ASEAN permitted_uv_filter 10% -
ASEAN permitted_uv_filter 10% -

Additional Ingredient Properties

1 property record from structured ingredient metadata.

sunscreen_uv
{"cas_number": "154702-15-5", "uv_filter_type": "organic_UVB", "chemical_class": "triazine", "absorption_spectrum_nm_range": "290-320", "peak_absorption_wavelength_nm": "312", "molar_extinction_coefficient": "48500", "critical_wavelength_nm": "325", "UVA_PF": "3-5", "SPF_contribution_per_percent": "11.2", "photostability_rating": "photostable", "photodegradation_half_life_hours": ">20", "photostab…

Function Categories & List Membership

Cosmetic/Chemical Function Categories
UV stabilizer
Regulatory List Membership (2)
EU Regulated in Personal Care EU CosIng Cosmetics Ingredient Database

Expert Verdict

Expert safety assessment and concern-level summary for Uvasorb HEB (Diethylhexyl Butamido Triazone).

Regulatory Flags

eu_cosing_listed

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Uvasorb HEB (Diethylhexyl Butamido Triazone) by CAS number or substance name.

Studies
3
Lowest NOAEL
500 mg/kg bw/day
Highest NOAEL
963 mg/kg bw/day
ToxValDB_ECHA_IUCLID

Known Synonyms

Bis(2-ethylhexyl) 4,4'-({6-[4-(tert-butylcarbamoyl)anilino]-1,3,5-triazine-2,4-diyl}diazanediyl)dibenzoate 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Uvasorb HEB

Chemical Function

UV stabilizer

Regulatory Lists

Canada; pharmaceutical

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

Compound
ISCOTRIZINOL
ChEMBL ID
CHEMBL2103813
Max Phase
-1
View full pharmaceutical profile →

Frequently Asked Questions

Is Uvasorb HEB (Diethylhexyl Butamido Triazone) safe in cosmetics?

Uvasorb HEB (Diethylhexyl Butamido Triazone) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 3 toxicological study endpoint(s) are available in our database.

Is Uvasorb HEB (Diethylhexyl Butamido Triazone) allowed in the EU?

Uvasorb HEB (Diethylhexyl Butamido Triazone) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Uvasorb HEB (Diethylhexyl Butamido Triazone) do in cosmetics?

Uvasorb HEB (Diethylhexyl Butamido Triazone) functions as: UV Filter. It is classified as a UV Filter / Sunscreen in our database. CAS number: 154702-15-5.

What is the NOAEL for Uvasorb HEB (Diethylhexyl Butamido Triazone)?

The NOAEL (No Observed Adverse Effect Level) for Uvasorb HEB (Diethylhexyl Butamido Triazone) is =500 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.

Is Uvasorb HEB (Diethylhexyl Butamido Triazone) used outside cosmetics?

Uvasorb HEB (Diethylhexyl Butamido Triazone) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Compliance Tools

Check Uvasorb HEB (Diethylhexyl Butamido Triazone) compliance across multiple jurisdictions:

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Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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