Is Ubiquinone safe in cosmetics?
Ubiquinone has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. This ingredient has been reviewed by CIR Safety Assessment.
Ubiquinone
Also known as: Coenzyme Q(sub 10), CoQ(sub 10), EINECS 206-147-9, Emitolon, Heartcin (+15 more)
INCI: UBIQUINONE
Ubiquinone (CAS 303-98-0) is a cosmetic antioxidant functioning as Antioxidant; mitochondrial electron transport chain protector; anti-pollution. EU Regulation 1223/2009 status: permitted; 5 safety opinions reviewed (CIR Safety Assessment). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical and food safety data.
Function
Antioxidant; mitochondrial electron transport chain protector; anti-pollution active; HEV mitochondrial stress protectant; endogenous lipophilic antioxidant; energy metabolism cofactor
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Expert Panel found safe as used in cosmetics; widely used at 0.01–1% in anti-aging, anti-pollution, and mitochondrial protection formulations; no concentration restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ubiquinone.
Calculate MoS for your specific formulation with the MoS Calculator.
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
CIR Safety Assessment
April 14, 2022
Verdict: safe
NOAEL: 600 mg/kg/d (oral)
ne ingredients as used in cosmetic formulations. The Panel concluded that these 4 Ubiquinone ingredients are safe in the present practices of use and concentrations described in this safety assessment. The Panel noted that Hydroxydecyl Ubiquinone is a synthetic analog of Ubiquinone with a shorter chain structu
CIR Safety Assessment
April 14, 2022
Verdict: safe
NOAEL: 500 mg/kg/d (not specified)
ne ingredients as used in cosmetic formulations. The Panel concluded that these 4 Ubiquinone ingredients are safe in the present practices of use and concentrations described in this safety assessment. The Panel noted that Hydroxydecyl Ubiquinone is a synthetic analog of Ubiquinone with a shorter chain structu
CIR Safety Assessment
April 14, 2022
Verdict: safe
NOAEL: 200 mg/kg/d (oral)
ne ingredients as used in cosmetic formulations. The Panel concluded that these 4 Ubiquinone ingredients are safe in the present practices of use and concentrations described in this safety assessment. The Panel noted that Hydroxydecyl Ubiquinone is a synthetic analog of Ubiquinone with a shorter chain structu
CIR Safety Assessment
April 14, 2022
Verdict: safe
NOAEL: 1200 mg/kg/d (not specified)
ne ingredients as used in cosmetic formulations. The Panel concluded that these 4 Ubiquinone ingredients are safe in the present practices of use and concentrations described in this safety assessment. The Panel noted that Hydroxydecyl Ubiquinone is a synthetic analog of Ubiquinone with a shorter chain structu
CIR Safety Assessment
April 14, 2022
Verdict: safe
NOAEL: 1200 mg/kg/d (oral)
ne ingredients as used in cosmetic formulations. The Panel concluded that these 4 Ubiquinone ingredients are safe in the present practices of use and concentrations described in this safety assessment. The Panel noted that Hydroxydecyl Ubiquinone is a synthetic analog of Ubiquinone with a shorter chain structu
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
JPKR Japan/Korea Cosmetics
Japan (Restricted): max 0.03
Japan (Restricted): max 0.03%
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| JP | restricted | 0.03% | Wash-away: 0.03% | Leave-on: 0.03% | Mucosa: Prohibited |
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Face Cream | 0.05–0.3 | 1 | CIR Safety Assessment |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Pharmaceutical
Softener and conditioner
Editorial summary
Preliminary editorial summary for Ubiquinone — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
anti-pollution
hev-protection
mitochondrial-protector
lipophilic
age-related-decline
electron-transport-chain
endogenous
vitamin-e-synergy
anti-aging
Known Synonyms
Coenzyme Q(sub 10)
CoQ(sub 10)
EINECS 206-147-9
Emitolon
Heartcin
Inokiten
Justquinon
Terekol
Ubiquinone Q(sub 10)
Udekinon
Luvacor
Mitoquinone
Ubidecarenona
Ubidecarenonum
Coenzyme Q 10
UNII-EJ27X76M46
Co-enzyme Q-10
(all-E)-2,3-dimethoxy-5-methyl-6-(3,7,11,15,19,23,27,31-octamethyl-2,6,10,14,18,22,26,30-dotriacontaoctaenyl)-2,5-Cyclohexadiene-1,4-dione
(all-E)-2-(3,7,11,15,19,23,27,31,35,39-decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-dimethoxy-3-methyl-2,5-Cyclohexadiene-1,4-dione
2-(3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecaenyl)-5,6-dimethoxy-3-methyl-p-Benzoquinone
Chemical Function
Antioxidant
Softener and conditioner
Pharmaceutical
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
pharmaceutical
Canada; pharmaceutical
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
pharmaceutical
Canada; Personal care; Substances in PCP - Canada (4/2014)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
UBIDECARENONE
ChEMBL ID
CHEMBL454801
Max Phase
3
Adverse Event Associations
4018
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Coenzyme Q10
Food Category
preservative
Frequently Asked Questions
Is Ubiquinone allowed in the EU?
Ubiquinone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ubiquinone do in cosmetics?
Ubiquinone functions as: Antioxidant; mitochondrial electron transport chain protector; anti-pollution active; HEV mitochondrial stress protectant; endogenous lipophilic antioxidant; energy metabolism cofactor. It is classified as a Antioxidant in our database. CAS number: 303-98-0.
Is Ubiquinone used outside cosmetics?
Ubiquinone also appears in pharmaceutical and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ubiquinone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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