Is Uvinul A Plus safe in cosmetics?
Uvinul A Plus has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Uvinul A Plus
Also known as: UNII-ANQ870JD20, Benzoic acid, 2-(4-(diethylamino)-2-hydroxybenzoyl)-, hexyl ester, Hexyl 2-(4-(diethylamino)-2-hydroxybenzoyl)benzoate
INCI: UVINUL A PLUS
Uvinul A Plus (CAS 302776-68-7) is a cosmetic uv filter / sunscreen functioning as UV Filter. NOAEL 166 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; 3 safety opinions reviewed (sccs). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 302776-68-7 →
Auto-generated CPSR Part A draft with source citations
Function
UV Filter
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Uvinul A Plus.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Uvinul A Plus. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 200 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | =200 mg/kg bw/day | oral | - | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg | oral | rat | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg bw/day | oral | - | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg | oral | rat | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg bw/day | oral | - | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg | oral | rat | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg bw/day | oral | - | developmental toxicity | SCCNFP_vision_codex |
| NOAEL | =200 mg/kg | oral | rat | NOAEL study | SCCNFP_vision_codex |
| NOAEL | =1350 mg/kg bw | oral | rat | NOAEL study | SCCNFP_vision_codex |
Safety Opinions
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
sccs
SCCS/1678/25
26 June 2025
Verdict: unknown
NOAEL: 5 mg/kg
bw/d (not specified)
Max Concentration: 10% in general
sccs
SCCS/1678/25
26 June 2025
Verdict: unknown
NOAEL: 2.5 mg/kg bw/d (oral)
Max Concentration: 10% in general
sccs
SCCS/1678/25
26 June 2025
Verdict: unknown
NOAEL: 5 mg/kg bw/d (oral)
Max Concentration: 10% in general
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Uvinul A Plus across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LOEL | =100 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOAEL | >=1000 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOAEL | =200 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOAEL | >=1440 mg/kg-day | Rat | oral | subchronic | ECHA IUCLID |
| NOAEL | =100 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOAEL | =300 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOAEL | =100 mg/kg-day | Rat | oral | - | ECHA IUCLID |
| NOAEL | =300 mg/kg-day | Rat | oral | - | ECHA IUCLID |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: UV filter
Receptor targets: ERα (limited)
LOEC: 10 µM
EU status: allowed (max 10%)
weak modulator
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex VI — Permitted UV Filters
Max: 10%
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: UV Filter. Max: 10%.
SA Saudi SFDA (VI - UV Filters)
Max: 0.1.
JPKR Japan/Korea Cosmetics
Japan (Positive (UV Absorber)): max 10.0
Korea (Restricted): max 10%
BRIN Brazil/India Cosmetics
India: Permitted UV Filter · max 0.1
Additional Jurisdictional Restrictions (3)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_uv_filter | 10 | All cosmetics |
| IN | permitted_uv_filter | 10.0 | sunscreen products only |
| BR | permitted_uv_filter | 10 | Sunscreen products |
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (3 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| default | 5.0 | method=default | - | - |
| default | 18.0 | method=default | - | - |
| default | 50.0 | method=default | - | - |
Additional Ingredient Properties
4 property records from structured ingredient metadata.
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "1", "skin_type_suitability": "all,oily,combination,normal,acne-prone", "acne_safe": "yes", "source": "UVA filter - EU"}
regulatory
{"eu_status": "allowed", "us_status": "allowed"}
sensory
{"silky": "powdery", "smooth, glides easily": "smooth, UVA filter", "dry-touch, non-greasy": "protected, invisible", "instant": "fast", "low": "low", "w/o": "o/w", "very-high": "excellent", "no": "no", "yes": "yes", "1.40": "1.58", "transparent": "opaque", "colorless": "pale-yellow", "excellent": "excellent", "light": "light", "synthetic": "synthetic"}
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "acceptable", "sensitive_skin": "acceptable", "combination_skin": "acceptable", "normal_skin": "acceptable", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "acceptable", "dehydrated": "acceptable", "skin_benefit_primary": "UV-protection", "skin_benefit_secondary": "UVA-filter", …
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
UV stabilizer
Regulatory List Membership (3)
EU Regulated in Personal Care
IFRA Fragrance Transparency List
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Uvinul A Plus.
Regulatory Flags
ifra_fragrance
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Uvinul A Plus by CAS number or substance name.
Studies
80
Lowest NOAEL
0.025
Highest NOAEL
2000
Units vary across source rows: mg/kg bw/d, mg/kg, mg/kg bw/day
SCCS_vision_codex
ToxValDB_ECHA_IUCLID
COSMOS_DB
SCCNFP_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 5.0 | method=default | - |
| 18.0 | method=default | - |
| 50.0 | method=default | - |
Known Synonyms
UNII-ANQ870JD20
Benzoic acid, 2-(4-(diethylamino)-2-hydroxybenzoyl)-, hexyl ester
Hexyl 2-(4-(diethylamino)-2-hydroxybenzoyl)benzoate
Chemical Function
UV stabilizer
Fragrance
Regulatory Lists
Europe; Personal care
IFRA Transparency
Canada; pharmaceutical
Australian Status
AICIS status: listed_with_terms
Assessment: This chemical has been assessed as a component of cosmetic products at concentrations no more than 10%.
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
diethylamino hydroxybenzoyl hexyl benzoate
Frequently Asked Questions
Is Uvinul A Plus allowed in the EU?
Uvinul A Plus EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Uvinul A Plus do in cosmetics?
Uvinul A Plus functions as: UV Filter. It is classified as a UV Filter / Sunscreen in our database. CAS number: 302776-68-7.
What is the NOAEL for Uvinul A Plus?
The NOAEL (No Observed Adverse Effect Level) for Uvinul A Plus is 200 mg/kg bw/day based on a Developmental study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Is Uvinul A Plus used outside cosmetics?
Uvinul A Plus also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Uvinul A Plus compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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