Is Ascorbyl Glucoside safe in cosmetics?
Ascorbyl Glucoside has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Ascorbyl Glucoside
Also known as: 2-O-Hexopyranosylhex-1-enofuranos-3-ulose, 2-O-α-D-Glucopyranosyl-L-ascorbic acid, (5R)-5-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-3-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2,5-dihydrofuran-2-one, AA 2G, Ascofresh (+1 more)
INCI: ASCORBYL GLUCOSIDE
Ascorbyl Glucoside (CAS 129499-78-1) is a cosmetic active ingredient functioning as Stable vitamin C derivative; tyrosinase inhibitor; antioxidant brightening. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 129499-78-1 →
Auto-generated CPSR Part A draft with source citations
Function
Stable vitamin C derivative; tyrosinase inhibitor; antioxidant brightening active; glucose-conjugated ascorbic acid released by alpha-glucosidase in skin
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restriction. Used in cosmetic brightening formulations without concentration limit.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ascorbyl Glucoside.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Ascorbyl Glucoside, relevant to systemic exposure and MoS calculations.
Absorption %
1-3%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
338.3 Da
Log P
-2.9
Systemic Absorption
minimal
Topical Bioavailability
0.5-2%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation
Source: Biosci Biotechnol Biochem 2005
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Typical Use Concentrations
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Serum | 1–5 | 10 | CIR/Industry |
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "129499-78-1", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restricti…
anti_pollution
{"cas_number": "129499-78-1", "ingredient_class": "antioxidant_pollution_shield", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5/UV_A", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_mo…
antioxidant
{"cas_number": "129499-78-1", "antioxidant_class": "vitamin", "chemical_subclass": "ascorbic acid glycoside", "molecular_weight_daltons": "338.26", "orac_value_umol_te_per_g": "900", "dpph_radical_scavenging_ic50_ug_per_ml": "40-60", "abts_trolox_equivalent": "0.5", "singlet_oxygen_quenching": "moderate", "superoxide_dismutase_mimetic": "low", "hydroxyl_radical_scavenging": "moderate", "lipid_pero…
comedogenicity_detail
{"comedogenicity_rating": "0", "irritancy_rating": "0", "skin_type_suitability": "all,oily,combination,normal,mature", "acne_safe": "yes", "source": "Stable vitamin C"}
concentration
{"min_concentration_pct": "0.5", "max_concentration_pct": "1.5", "typical_concentration_pct": "1.0", "product_type": "Moisturizer", "function_at_concentration": "Stable vitamin C derivative", "source": "Supplier TDS"}
depigmentation
{"cas_number": "129499-78-1", "ingredient_class": "melanin_oxidation_agent", "primary_mechanism_of_action": "Stable vitamin C derivative; converted to ascorbic acid by alpha-glucosidase", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reducti…
dermal_absorption
{"molecular_weight_da": "338.3", "log_p_value": "-2.9", "skin_penetration_level": "surface", "penetration_depth": "stratum corneum", "absorption_pct": "1-3", "systemic_absorption": "minimal", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "0.5-2", "safety_margin_factor": "low", "source": "Biosci B…
interactions
{"ingredient_2": "Salicylic Acid", "interaction_type": "pH_dependent", "severity": "caution", "effect": "SAP may not function optimally at low BHA pH", "recommendation": "Less compatible than other vitamin C derivatives", "data_source": "Formulation science literature, dermatological research, cosmetic chemistry best practices", "last_updated": "2026-03-05"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Expert Verdict
Expert safety assessment and concern-level summary for Ascorbyl Glucoside.
Regulatory Flags
cir-safe-as-used-2022
eu-unrestricted
superior-stability-glucose
neutral-ph-compatible
korea-functional-whitening-2pct
japan-quasi-drug-whitening
cosmos-approved-enzymatic
Known Synonyms
2-O-Hexopyranosylhex-1-enofuranos-3-ulose
2-O-α-D-Glucopyranosyl-L-ascorbic acid
(5R)-5-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-3-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-2,5-dihydrofuran-2-one
AA 2G
Ascofresh
EC 425-980-0
Chemical Function
Antioxidant
Regulatory Lists
Canada; pharmaceutical
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. You must tell us within 28 days if the circumstances of your importation or manufacture (introduction) are different to those in our assessment.
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2011961
Frequently Asked Questions
Is Ascorbyl Glucoside allowed in the EU?
Ascorbyl Glucoside EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ascorbyl Glucoside do in cosmetics?
Ascorbyl Glucoside functions as: Stable vitamin C derivative; tyrosinase inhibitor; antioxidant brightening active; glucose-conjugated ascorbic acid released by alpha-glucosidase in skin. It is classified as a Active Ingredient in our database. CAS number: 129499-78-1.
Is Ascorbyl Glucoside used outside cosmetics?
Ascorbyl Glucoside also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ascorbyl Glucoside compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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