Excellent Active Ingredient Dermal Penetration

Ascorbyl Glucoside

INCI: ASCORBYL GLUCOSIDE

CAS Number
129499-78-1
Function
Stable vitamin C derivative; tyrosinase inhibitor; antioxidant brightening active; glucose-conjugated ascorbic acid released by alpha-glucosidase in skin
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes No FDA restriction. Used in cosmetic brightening formulations without concentration limit.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Ascorbyl Glucoside, relevant to systemic exposure and MoS calculations.

Absorption %
1-3%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
338.3 Da
Log P
-2.9
Systemic Absorption
minimal
Topical Bioavailability
0.5-2%
Safety Margin Factor
low
Vehicle Dependent
Yes — absorption varies by formulation

Source: Biosci Biotechnol Biochem 2005

Expert Verdict

CIR safe as used (2022 update). Superior stability due to glucose moiety protecting the enediol group. Works at neutral pH (6-7) unlike L-ascorbic acid. Hydrophilic structure. EU unrestricted. Korea MFDS approved whitening active. Japan quasi-drug whitening. COSMOS approved via enzymatic process.

⚠️
Concern Level: None

Regulatory Flags

cir-safe-as-used-2022 eu-unrestricted superior-stability-glucose neutral-ph-compatible korea-functional-whitening-2pct japan-quasi-drug-whitening cosmos-approved-enzymatic

Frequently Asked Questions

Is Ascorbyl Glucoside safe in cosmetics?

CIR safe as used (2022 update). Superior stability due to glucose moiety protecting the enediol group. Works at neutral pH (6-7) unlike L-ascorbic acid. Hydrophilic structure. EU unrestricted. Korea MFDS approved whitening active. Japan quasi-drug whitening. COSMOS approved via enzymatic process. The EU classifies Ascorbyl Glucoside as "permitted". Safety rating: EXCELLENT.

Is Ascorbyl Glucoside allowed in the EU?

Ascorbyl Glucoside EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ascorbyl Glucoside do in cosmetics?

Ascorbyl Glucoside functions as: Stable vitamin C derivative; tyrosinase inhibitor; antioxidant brightening active; glucose-conjugated ascorbic acid released by alpha-glucosidase in skin. It is classified as a Active Ingredient in our database. CAS number: 129499-78-1.

What is the Margin of Safety for Ascorbyl Glucoside?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check Ascorbyl Glucoside compliance across multiple jurisdictions:

🔬
Ingredient Decoder
Paste a full ingredient list for instant analysis
 🌸
82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
 🧮
MoS Calculator
Calculate Margin of Safety using SCCS methodology
 ⚗️
Heavy Metal Limits
Compare limits across jurisdictions

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