Excellent Active Ingredient Dermal Penetration

Asiaticoside

INCI: ASIATICOSIDE

CAS Number
16830-15-2
Function
anti-inflammatory, wound-healing, barrier-repair
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted; no US concentration cap. Co-active with madecassoside in Centella asiatica triterpene extract. Used at 0.1โ€“1% in leave-on formulations.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Dermal Penetration Profile

Skin absorption and penetration characteristics of Asiaticoside, relevant to systemic exposure and MoS calculations.

Absorption %
0.5-2%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
959.1 Da
Log P
-2.2
Systemic Absorption
minimal
Topical Bioavailability
0.2-1%
Safety Margin Factor
minimal
Vehicle Dependent
Yes โ€” absorption varies by formulation

Source: Phytomedicine 2010

Expert Verdict

Excellent wound-healing and barrier-repair active from Centella asiatica that stimulates type I collagen synthesis, promotes fibroblast proliferation, upregulates filaggrin and involucrin expression, and inhibits NF-ฮบB-mediated inflammatory pathways. Frequently formulated with madecassoside for synergistic barrier repair and anti-inflammatory benefit.

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Concern Level: None

Regulatory Flags

active wound-healing anti-inflammatory barrier-repair collagen-stimulator filaggrin-booster involucrin-booster nf-kb-inhibitor centella-asiatica botanical atopic-dermatitis-target sensitive-skin

Frequently Asked Questions

Is Asiaticoside safe in cosmetics?

Excellent wound-healing and barrier-repair active from Centella asiatica that stimulates type I collagen synthesis, promotes fibroblast proliferation, upregulates filaggrin and involucrin expression, and inhibits NF-ฮบB-mediated inflammatory pathways. Frequently formulated with madecassoside for synergistic barrier repair and anti-inflammatory benefit. The EU classifies Asiaticoside as "permitted". Safety rating: EXCELLENT.

Is Asiaticoside allowed in the EU?

Asiaticoside EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Asiaticoside do in cosmetics?

Asiaticoside functions as: anti-inflammatory, wound-healing, barrier-repair. It is classified as a Active Ingredient in our database. CAS number: 16830-15-2.

What is the Margin of Safety for Asiaticoside?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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