Excellent Active Ingredient

Bemotrizinol

INCI: BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE

CAS Number
187393-00-6
Function
Broad-spectrum oil-soluble organic UV filter with dual absorption peaks at approximately 310 nm and 340 nm. Photostabilizer for avobenzone and other photolabile filters via triplet-state energy dissipation through S1โ†’S0 internal conversion pathway. High molecular weight of 627 Da results in minimal skin penetration and surface-film behavior.
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
EU Max Conc. 10%
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes FDA Proposed Administrative Order OTC000039 (December 2025) proposes GRASE status at up to 6%. Initiated by DSM-Firmenich Tier 1 OMOR (September 2024). FDA noted low skin absorption and rare skin irritation. GRASE determination anticipated by March 2026. If finalized, would be the first new Category I UV filter added to the US monograph. Final order may follow in mid-to-late 2026 before market availability.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Best-in-class broad-spectrum organic UV filter with outstanding safety and efficacy profile. Dual UV peaks at approximately 310 nm and 340 nm with photostability and high molecular weight (627 Da) that remains on skin surface. No endocrine activity confirmed in regulatory assessment. Functions as triplet-state quencher stabilizing avobenzone and other photolabile filters. Approved at 10% in EU, Australia, and Japan with over a decade of safe global use. FDA Proposed Administrative Order OTC000039 proposes GRASE status at 6% with determination anticipated March 2026, which would make it the first new US monograph sunscreen ingredient since 1999.

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Concern Level: None

Regulatory Flags

uv-filter broad-spectrum uva-uvb photostable high-mw surface-film eu-approved fda-proposed-grase-dec-2025 grase-anticipated-march-2026 avobenzone-stabilizer triplet-quencher oil-soluble reef-friendly no-endocrine-activity 627-da eu_cosing_listed

Frequently Asked Questions

Is Bemotrizinol safe in cosmetics?

Best-in-class broad-spectrum organic UV filter with outstanding safety and efficacy profile. Dual UV peaks at approximately 310 nm and 340 nm with photostability and high molecular weight (627 Da) that remains on skin surface. No endocrine activity confirmed in regulatory assessment. Functions as triplet-state quencher stabilizing avobenzone and other photolabile filters. Approved at 10% in EU, Australia, and Japan with over a decade of safe global use. FDA Proposed Administrative Order OTC000039 proposes GRASE status at 6% with determination anticipated March 2026, which would make it the first new US monograph sunscreen ingredient since 1999. The EU classifies Bemotrizinol as "permitted". Safety rating: EXCELLENT.

Is Bemotrizinol allowed in the EU?

Bemotrizinol EU regulatory status: permitted. Maximum allowed concentration: 10%. This is based on EU Regulation 1223/2009 and its amendments.

What does Bemotrizinol do in cosmetics?

Bemotrizinol functions as: Broad-spectrum oil-soluble organic UV filter with dual absorption peaks at approximately 310 nm and 340 nm. Photostabilizer for avobenzone and other photolabile filters via triplet-state energy dissipation through S1โ†’S0 internal conversion pathway. High molecular weight of 627 Da results in minimal skin penetration and surface-film behavior.. It is classified as a Active Ingredient in our database. CAS number: 187393-00-6.

What is the Margin of Safety for Bemotrizinol?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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