Is Bemotrizinol safe in cosmetics?
Bemotrizinol has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: restricted.
EXCELLENT
Active Ingredient
Bemotrizinol
Also known as: Phenol, 2,2'-(6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)-
INCI: BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE
Bemotrizinol (CAS 187393-00-6) is a cosmetic active ingredient functioning as Broad-spectrum oil-soluble organic UV filter with dual absorption peaks at. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted, max 10%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 187393-00-6 →
Function
Broad-spectrum oil-soluble organic UV filter with dual absorption peaks at approximately 310 nm and 340 nm. Photostabilizer for avobenzone and other photolabile filters via triplet-state energy dissipation through S1→S0 internal conversion pathway. High molecular weight of 627 Da results in minimal skin penetration and surface-film behavior.
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
EU Max Conc.
10%
US US Status
restricted
US Notes
FDA Proposed Administrative Order OTC000039 (December 2025) proposes GRASE status at up to 6%. Initiated by DSM-Firmenich Tier 1 OMOR (September 2024). FDA noted low skin absorption and rare skin irritation. GRASE determination anticipated by March 2026. If finalized, would be the first new Category I UV filter added to the US monograph. Final order may follow in mid-to-late 2026 before market availability.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Bemotrizinol.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Bemotrizinol across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LC50 | >649 mg/m3 | Rat | inhalation | - | ECHA |
| LD50 | >2000 mg/kg | Rat | dermal | acute | ECHA |
| LD50 | >2000 mg/kg | Rat | dermal | acute | ECHA |
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA |
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA |
| LEL | =649 mg/m3 | Rat | inhalation | - | ECHA |
| LEL | ~0.075 mg/cm2-day | Rat | dermal | chronic | ECHA |
| NOAEL | >=1000 mg/kg-day | Rat | dermal | - | ECHA |
| NOAEL | >=1000 mg/kg-day | Rat | dermal | - | ECHA |
| NOAEL | >=1000 mg/kg-day | Rabbit | oral | - | ECHA |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: UV filter
Receptor targets: none confirmed in standard assays
LOEC: N/A
EU status: allowed (max 10%)
no significant ER/AR activity
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex VI — Permitted UV Filters
Max: 10%
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: UV Filter. Max: 10%.
SA Saudi SFDA (VI - UV Filters)
Max: 0.1.
JPKR Japan/Korea Cosmetics
Japan (Positive (UV Absorber)): max 3.0
Korea (Restricted): max 10%
BRIN Brazil/India Cosmetics
India: Permitted UV Filter · max 0.1
Additional Jurisdictional Restrictions (6)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_uv_filter | 10 | All cosmetics |
| IN | permitted_uv_filter | 10.0 | sunscreen and other cosmetic products |
| IN | permitted_uv_filter | 10.0 | sunscreen and other cosmetic products |
| GCC | restricted | 10.0 | Sunscreen products |
| BR | permitted_uv_filter | 10 | Sunscreen products |
| ASEAN | permitted_uv_filter | 10% | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
UV stabilizer
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Editorial summary
Preliminary editorial summary for Bemotrizinol — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
uv-filter
broad-spectrum
uva-uvb
photostable
high-mw
surface-film
eu-approved
fda-proposed-grase-dec-2025
grase-anticipated-march-2026
avobenzone-stabilizer
triplet-quencher
oil-soluble
reef-friendly
no-endocrine-activity
627-da
eu_cosing_listed
Known Synonyms
Phenol, 2,2'-(6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)-
Chemical Function
UV stabilizer
Softener and conditioner
Regulatory Lists
Europe; Personal care
pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed_with_terms
Specific information requirements: Obligations to provide information apply. These obligations are: 1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the...
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BEMOTRIZINOL
ChEMBL ID
CHEMBL2104956
Max Phase
3
Frequently Asked Questions
Is Bemotrizinol allowed in the EU?
Bemotrizinol EU regulatory status: permitted. Maximum allowed concentration: 10%. This is based on EU Regulation 1223/2009 and its amendments.
What does Bemotrizinol do in cosmetics?
Bemotrizinol functions as: Broad-spectrum oil-soluble organic UV filter with dual absorption peaks at approximately 310 nm and 340 nm. Photostabilizer for avobenzone and other photolabile filters via triplet-state energy dissipation through S1→S0 internal conversion pathway. High molecular weight of 627 Da results in minimal skin penetration and surface-film behavior.. It is classified as a Active Ingredient in our database. CAS number: 187393-00-6.
Is Bemotrizinol used outside cosmetics?
Bemotrizinol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Bemotrizinol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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