Moderate Fragrance Sensitization Data Dermal Penetration

Benzyl Cinnamate

INCI: BENZYL CINNAMATE

Benzyl Cinnamate (CAS None) is a cosmetic fragrance functioning as fragrance; fixative. EU Regulation 1223/2009 status: restricted, max Declarable EU allergen; labelling required >10 ppm leave-on / >100 ppm rinse-off. Industrial safety data is also available in the chemical safety database.

View industrial chemical safety profile for CAS None →

Auto-generated CPSR Part A draft with source citations
Function
fragrance; fixative
Safety Rating
MODERATE

Regulatory Status

EU EU Status restricted
EU Max Conc. Declarable EU allergen; labelling required >10 ppm leave-on / >100 ppm rinse-off
US US Status permitted
US Notes Permitted; RIFM-assessed; allergen declaration required for EU market

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Benzyl Cinnamate.

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Benzyl Cinnamate based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
0.3%
Cross-reactivity Group
balsam-of-peru-group
Reaction Type
contact-dermatitis
IFRA Restricted

Source: ESSCA/IVDK

Dermal Penetration Profile

Skin absorption and penetration characteristics of Benzyl Cinnamate, relevant to systemic exposure and MoS calculations.

Absorption %
12-22%
Penetration Level
epidermis
Penetration Depth
epidermis
Molecular Weight
238.3 Da
Log P
4.6
Systemic Absorption
minimal
Topical Bioavailability
8-18%
Safety Margin Factor
moderate
Vehicle Dependent
Yes — absorption varies by formulation

Source: SCCS/1459/11, IFRA

IFRA Concentration Limits (12 Product Categories)

International Fragrance Association standards per product category. Restriction: Restriction. Effective: 2021-02-10.

Category Max % Category Max %
1 (Lip products) 0.11% 7a (Deodorant – not spray) 0.19%
2 (Body spray) 0.032% 7b (Deodorant spray) 0.19%
3 (Body cream) 0.12% 8 (Face cream) 0.031%
4 (Fine fragrance) 0.38% 9 (Soap) 0.38%
5a (Body lotion) 0.094% 10a (Household – non-spray) 0.38%
5b (Face cream leave-on) 0.094% 10b (Household – spray) 0.75%
5c (Hand cream) 0.094% 11a (Intimate – leave-on) 0.031%
5d (Baby cream) 0.031% 11b (Intimate – rinse) 0.031%
6 (Mouthwash) 0.12% 12 (Not for consumer exposure) No Restriction%

Additional Ingredient Properties

4 property records from structured ingredient metadata.

allergen_detail
{"eu_allergen_listed": "yes", "allergen_class": "fragrance", "cross_reactivity_group": "balsam-of-peru-group", "patch_test_frequency_pct": "0.3", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "yes", "source": "ESSCA/IVDK"}
dermal_absorption
{"molecular_weight_da": "238.3", "log_p_value": "4.6", "skin_penetration_level": "epidermis", "penetration_depth": "epidermis", "absorption_pct": "12-22", "systemic_absorption": "minimal", "penetration_enhancer": "yes", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "neutral", "bioavailability_topical_pct": "8-18", "safety_margin_factor": "moderate", "source": "SCCS/1…
fragrance
{"cas_number": "103-41-3", "ingredient_class": "aroma_chemical", "chemical_class": "ester", "odor_family": "floral", "odor_description": "Sweet balsamic, honey-like with fruity notes", "odor_strength": "medium", "odor_tenacity_hours": "48.0", "top_note": "no", "heart_note": "yes", "base_note": "yes", "blending_factor_1_10": "6.0", "threshold_of_detection_ppb": "80.0", "molecular_weight_Da": "238.2…
regulatory
{"eu_status": "restricted", "us_status": "allowed", "eu_max_concentration": "0.001", "restricted_in": "rinse-off: >0.01%, leave-on: >0.001%", "regulation_reference": "Annex III/205"}

Expert Verdict

Expert safety assessment and concern-level summary for Benzyl Cinnamate.

Regulatory Flags

allergen-eu sensitization-risk eu-labelling-required original-26-allergen eu_children_restricted ifra_fragrance fda_food_additive eu_cosing_listed jecfa_safe

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Benzyl Cinnamate by CAS number or substance name.

Studies
6
Lowest NOAEL
600 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
COSMOS_DB ToxValDB_ECHA_IUCLID ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip

Frequently Asked Questions

Is Benzyl Cinnamate safe in cosmetics?

Benzyl Cinnamate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.

Is Benzyl Cinnamate allowed in the EU?

Benzyl Cinnamate EU regulatory status: restricted. Maximum allowed concentration: Declarable EU allergen; labelling required >10 ppm leave-on / >100 ppm rinse-off. This is based on EU Regulation 1223/2009 and its amendments.

What does Benzyl Cinnamate do in cosmetics?

Benzyl Cinnamate functions as: fragrance; fixative. It is classified as a Fragrance in our database. CAS number: None.

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