Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Excellent immunomodulatory and film-forming polysaccharide with two key mechanisms: (1) immunomodulatory—stimulates macrophage activity and promotes wound healing via keratinocyte migration while modulating pro-inflammatory cytokine output; (2) film-forming—deposits a hydration-retaining film on the stratum corneum surface sustaining moisturizing effects up to 2 weeks after product discontinuation. Exceptionally low sensitization profile confirmed by HRIPT (1.0% induction reactions only) and real-world data (0 consumer allergies across 445,820 products over 3 years). Closely related to FDA-approved colloidal oatmeal skin protectant. Effective at 0.1–0.5%. Not restricted in EU or US.
Regulatory Flags
Frequently Asked Questions
Is Beta-Glucan safe in cosmetics?
Excellent immunomodulatory and film-forming polysaccharide with two key mechanisms: (1) immunomodulatory—stimulates macrophage activity and promotes wound healing via keratinocyte migration while modulating pro-inflammatory cytokine output; (2) film-forming—deposits a hydration-retaining film on the stratum corneum surface sustaining moisturizing effects up to 2 weeks after product discontinuation. Exceptionally low sensitization profile confirmed by HRIPT (1.0% induction reactions only) and real-world data (0 consumer allergies across 445,820 products over 3 years). Closely related to FDA-approved colloidal oatmeal skin protectant. Effective at 0.1–0.5%. Not restricted in EU or US. The EU classifies Beta-Glucan as "permitted". Safety rating: EXCELLENT.
Is Beta-Glucan allowed in the EU?
Beta-Glucan EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Beta-Glucan do in cosmetics?
Beta-Glucan functions as: Skin-conditioning agent, humectant, immunomodulator (beta-1,3/1,6-glucan; anti-inflammatory; moisture retention; stimulates skin immune defense). It is classified as a Active Ingredient in our database. CAS number: 26874-89-5.
What is the Margin of Safety for Beta-Glucan?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Beta-Glucan compliance across multiple jurisdictions:
Related Ingredients
Is Beta-Glucan in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Beta-Glucan in your formulation.