Excellent Active Ingredient NOAEL Data

Camellia Sinensis Leaf Extract

INCI: CAMELLIA SINENSIS LEAF EXTRACT

CAS Number
84650-60-2
Function
Antioxidant, Skin conditioning, Anti-inflammatory
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Cosmetic ingredient. No FDA concentration restrictions.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

2 study endpoints found for Camellia Sinensis Leaf Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 20000 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB
dose_tested 20000 mg/kg bw/day oral rat Special Toxicology Study COSMOS_DB

Expert Verdict

Camellia Sinensis Leaf Extract (green tea extract) contains catechins (EGCG, EGC, ECG, EC) with ROS-scavenging and anti-inflammatory activity. Well-tolerated across sensitive and rosacea-prone skin populations with topical bioavailability sufficient for surface antioxidant protection at cosmetic concentrations. Unrestricted in EU and US.

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Concern Level: None

Regulatory Flags

rosacea-safe antioxidant anti-inflammatory ros-scavenging stability-sensitive eu_children_restricted fda_food_additive

Frequently Asked Questions

Is Camellia Sinensis Leaf Extract safe in cosmetics?

Camellia Sinensis Leaf Extract (green tea extract) contains catechins (EGCG, EGC, ECG, EC) with ROS-scavenging and anti-inflammatory activity. Well-tolerated across sensitive and rosacea-prone skin populations with topical bioavailability sufficient for surface antioxidant protection at cosmetic concentrations. Unrestricted in EU and US. The EU classifies Camellia Sinensis Leaf Extract as "permitted". Safety rating: EXCELLENT. 2 toxicological study endpoint(s) are available in our database.

Is Camellia Sinensis Leaf Extract allowed in the EU?

Camellia Sinensis Leaf Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Camellia Sinensis Leaf Extract do in cosmetics?

Camellia Sinensis Leaf Extract functions as: Antioxidant, Skin conditioning, Anti-inflammatory. It is classified as a Active Ingredient in our database. CAS number: 84650-60-2.

What is the Margin of Safety for Camellia Sinensis Leaf Extract?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Camellia Sinensis Leaf Extract?

The NOAEL (No Observed Adverse Effect Level) for Camellia Sinensis Leaf Extract is 20000 mg/kg bw/day based on a Special Toxicology Study study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.

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