Excellent Active Ingredient

Ceramide NS

INCI: CERAMIDE NS

CAS Number
100403-19-8
Function
Ceramide 2 (N-stearoyl sphingosine). Non-hydroxy fatty acid sphingosine ceramide. Lamellar lipid component providing structural rigidity and water barrier function in stratum corneum. Works synergistically with ceramides NP, AP, and EOP in triple-lipid system.
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted without restriction. Part of multi-ceramide longevity skincare formulations. Most effective in combination with ceramides NP, AP, EOP, cholesterol, and free fatty acids. MoCRA safety substantiation required.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Ceramide NS is a core stratum corneum component providing structural barrier function, unrestricted globally with endogenous lipid status and excellent safety profile.

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Concern Level: None

Regulatory Flags

ceramide barrier-function longevity-skincare skin-identical evidence-backed anti-aging

Frequently Asked Questions

Is Ceramide NS safe in cosmetics?

Ceramide NS is a core stratum corneum component providing structural barrier function, unrestricted globally with endogenous lipid status and excellent safety profile. The EU classifies Ceramide NS as "permitted". Safety rating: EXCELLENT.

Is Ceramide NS allowed in the EU?

Ceramide NS EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Ceramide NS do in cosmetics?

Ceramide NS functions as: Ceramide 2 (N-stearoyl sphingosine). Non-hydroxy fatty acid sphingosine ceramide. Lamellar lipid component providing structural rigidity and water barrier function in stratum corneum. Works synergistically with ceramides NP, AP, and EOP in triple-lipid system.. It is classified as a Active Ingredient in our database. CAS number: 100403-19-8.

What is the Margin of Safety for Ceramide NS?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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