Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
4 study endpoints found for Musk Ketone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 125 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 10 mg/kg bw/day | oral | mouse | Special Toxicology Study | COSMOS_DB |
| NOAEL | 45 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | 20 mg/kg bw/day | oral | rat | Special Toxicology Study | COSMOS_DB |
Sensitization Profile
Contact sensitization data for Musk Ketone based on clinical patch test studies and IFRA standards.
Source: IFRA/SCCS
Expert Verdict
Second commercially significant nitro musk alongside musk xylene with lower acute human toxicity concern than musk xylene but sharing environmental persistence and bioaccumulation profile. Industry consensus and IFRA 51st Amendment trajectory is toward full elimination; avoid in clean-beauty and EU-forward formulations.
Regulatory Flags
Frequently Asked Questions
Is Musk Ketone safe in cosmetics?
Second commercially significant nitro musk alongside musk xylene with lower acute human toxicity concern than musk xylene but sharing environmental persistence and bioaccumulation profile. Industry consensus and IFRA 51st Amendment trajectory is toward full elimination; avoid in clean-beauty and EU-forward formulations. The EU classifies Musk Ketone as "restricted". Safety rating: MODERATE. 4 toxicological study endpoint(s) are available in our database.
Is Musk Ketone allowed in the EU?
Musk Ketone EU regulatory status: restricted. Maximum allowed concentration: 1.4% fine fragrance; 0.56% eau de toilette; 0.042% other cosmetic products. This is based on EU Regulation 1223/2009 and its amendments.
What does Musk Ketone do in cosmetics?
Musk Ketone functions as: Fragrance fixative (nitro-musk, warm powdery sweet musky odor). It is classified as a Fragrance in our database. CAS number: 81-14-1.
What is the Margin of Safety for Musk Ketone?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Musk Ketone?
The NOAEL (No Observed Adverse Effect Level) for Musk Ketone is 125 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 4 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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