Poor Fragrance Sensitization Data

Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde

INCI: HYDROXYISOHEXYL 3-CYCLOHEXENE CARBOXALDEHYDE

CAS Number
31906-04-4
Function
Fragrance ingredient
Safety Rating
POOR

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status prohibited
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Not federally banned in US; IFRA has imposed extremely low or zero use limits across all product categories

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
moderate
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Sensitization Profile

Contact sensitization data for Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde based on clinical patch test studies and IFRA standards.

Sensitization Rate
moderate
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
2.7%
Cross-reactivity Group
fragrance-mix-II
Reaction Type
contact-dermatitis
IFRA Restricted

Source: ESSCA/SCCS (banned 2021)

Expert Verdict

Potent contact sensitizer banned from all EU cosmetic products under Regulation EU 2023/1545; IFRA restricts to near-zero levels; must not be used in EU-marketed cosmetics.

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Concern Level: High

Regulatory Flags

fragrance-allergen eu-prohibited eu-annex-ii fm-ii patch-test-standard banned potent-sensitizer lyral eu_children_restricted ifra_fragrance

Frequently Asked Questions

Is Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde safe in cosmetics?

Potent contact sensitizer banned from all EU cosmetic products under Regulation EU 2023/1545; IFRA restricts to near-zero levels; must not be used in EU-marketed cosmetics. The EU classifies Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde as "prohibited". Safety rating: POOR.

Is Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde allowed in the EU?

Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde do in cosmetics?

Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde functions as: Fragrance ingredient. It is classified as a Fragrance in our database. CAS number: 31906-04-4.

What is the Margin of Safety for Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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