Is Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde safe in cosmetics?
Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde has a safety rating of "POOR" in our database. EU status: prohibited. US status: permitted.
Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde
Also known as: 3-Cyclohexene-1-carboxaldehyde, 4-(4-hydroxy-4-methylpentyl)-, BRN 2046455, EINECS 250-863-4, 4-(4-Hydroxy-4-methylpentyl)-3-cyclohexene-1-carboxaldehyde, UNII-QUE43B9Z2Q
INCI: HYDROXYISOHEXYL 3-CYCLOHEXENE CARBOXALDEHYDE
Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde (CAS 31906-04-4) is a cosmetic fragrance functioning as Fragrance ingredient. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 31906-04-4 →
Function
Fragrance ingredient
Editorial assessment
POOR
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Not federally banned in US; IFRA has imposed extremely low or zero use limits across all product categories
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization Profile
Contact sensitization data for Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde based on clinical patch test studies and IFRA standards.
Sensitization Rate
moderate
Allergen Class
fragrance
EU Allergen Listed
yes
Patch Test Positive Rate
2.7%
Cross-reactivity Group
fragrance-mix-II
Reaction Type
contact-dermatitis
IFRA Restricted
Source: SCCS Opinion
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 201 | 0 | 4000 | 4000 | non-sensitizer |
| HMT | - | 0 | 6750 | - | - |
| HRIPT | - | 0 | 775 | - | - |
| HRIPT | - | 0 | 3100.01 | - | - |
| HRIPT | - | 0 | 8264 | - | - |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: fragrance
Receptor targets: ERα (limited data)
LOEC: 100 µM
EU status: banned (allergen; Annex II)
weak modulator
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
ASEAN Cosmetic Directive (II)
Ref: 1380
BRIN Brazil/India Cosmetics
Brazil: Restricted (Fragrance Allergen) · max >0.001% leave-on / >0.01% rinse-off requires labeling
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| GCC | banned | - | All cosmetics |
| KR | prohibited | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Fragrance
Regulatory List Membership (3)
EU Restricted for Children (Cosmetics)
IFRA Fragrance Transparency List
Consumer Product Chemical
Editorial summary
Preliminary editorial summary for Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
fragrance-allergen
eu-prohibited
eu-annex-ii
fm-ii
patch-test-standard
banned
potent-sensitizer
lyral
eu_children_restricted
ifra_fragrance
Known Synonyms
3-Cyclohexene-1-carboxaldehyde, 4-(4-hydroxy-4-methylpentyl)-
BRN 2046455
EINECS 250-863-4
4-(4-Hydroxy-4-methylpentyl)-3-cyclohexene-1-carboxaldehyde
UNII-QUE43B9Z2Q
Chemical Function
Fragrance
Regulatory Lists
IFRA Transparency
consumer_product
inert_ingredient; non_food_use; Pesticides
Europe
children; Europe; Personal care - specialized bath products - bath salts
children; Europe; Personal care
Cleaning products and household care - air freshener; detected; Europe; Vehicle - car interior - auto air freshener
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
LYRAL
ChEMBL ID
CHEMBL3182066
Max Phase
-1
Frequently Asked Questions
Is Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde allowed in the EU?
Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde do in cosmetics?
Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde functions as: Fragrance ingredient. It is classified as a Fragrance in our database. CAS number: 31906-04-4.
Is Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde used outside cosmetics?
Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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HICC (Hydroxyisohexyl 3-Cyclohexene Carboxaldehyde)
GOOD
Chemical family
Fragrance ingredient
Vinyl Cyclohexene Carboxaldehyde (HICC/Lyral®)
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Chemical family
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HYDRASTIS CANADENSIS EXTRACT
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