Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Madecassoside, relevant to systemic exposure and MoS calculations.
Source: Arch Pharm Res 2012
Expert Verdict
Excellent multi-mechanism barrier-repair and anti-inflammatory active from Centella asiatica with clinically relevant mechanisms including TEWL reduction, filaggrin and involucrin upregulation, NF-ฮบB pathway inhibition, and collagen synthesis support. Not restricted in EU or US.
Regulatory Flags
Frequently Asked Questions
Is Madecassoside safe in cosmetics?
Excellent multi-mechanism barrier-repair and anti-inflammatory active from Centella asiatica with clinically relevant mechanisms including TEWL reduction, filaggrin and involucrin upregulation, NF-ฮบB pathway inhibition, and collagen synthesis support. Not restricted in EU or US. The EU classifies Madecassoside as "permitted". Safety rating: EXCELLENT.
Is Madecassoside allowed in the EU?
Madecassoside EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Madecassoside do in cosmetics?
Madecassoside functions as: anti-inflammatory, wound-healing, barrier-repair. It is classified as a Active Ingredient in our database. CAS number: 34540-22-2.
What is the Margin of Safety for Madecassoside?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
Check Madecassoside compliance across multiple jurisdictions:
Related Ingredients
Is Madecassoside in Your Products?
Scan any product label with Piro โ our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free โAnalyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Madecassoside in your formulation.