Is Madecassoside safe in cosmetics?
Madecassoside has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Madecassoside
INCI: MADECASSOSIDE
Madecassoside (CAS 34540-22-2) is a cosmetic active ingredient functioning as anti-inflammatory, wound-healing, barrier-repair. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 34540-22-2 →
Function
anti-inflammatory, wound-healing, barrier-repair
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; no US concentration cap. Purified triterpene glycoside from Centella asiatica. Used at 0.1–1% in leave-on formulations for barrier repair, anti-inflammatory, and wound-healing applications.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Madecassoside.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Madecassoside, relevant to systemic exposure and MoS calculations.
Absorption %
0.5-2%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
975.1 Da
Log P
-2.5
Systemic Absorption
minimal
Topical Bioavailability
0.2-1%
Safety Margin Factor
minimal
Vehicle Dependent
Yes — absorption varies by formulation
Source: Arch Pharm Res 2012
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Editorial summary
Preliminary editorial summary for Madecassoside — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
active
wound-healing
anti-inflammatory
barrier-repair
collagen-stimulator
filaggrin-booster
involucrin-booster
nf-kb-inhibitor
tewl-reduction
ceramide-synthesis-enhancer
centella-asiatica
botanical
atopic-dermatitis-target
sensitive-skin
Chemical Function
Antioxidant
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL4787233
Frequently Asked Questions
Is Madecassoside allowed in the EU?
Madecassoside EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Madecassoside do in cosmetics?
Madecassoside functions as: anti-inflammatory, wound-healing, barrier-repair. It is classified as a Active Ingredient in our database. CAS number: 34540-22-2.
Is Madecassoside used outside cosmetics?
Madecassoside also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Madecassoside compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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