Is Palmitoyl Tripeptide-5 safe in cosmetics?
Palmitoyl Tripeptide-5 has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
EXCELLENT
Active Ingredient
Palmitoyl Tripeptide-5
INCI: PALMITOYL TRIPEPTIDE-5
Palmitoyl Tripeptide-5 (CAS None) is a cosmetic active ingredient functioning as Signal peptide (Syn-Coll, DSM/Pentapharm/Symrise) that mimics TGF-β. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
Function
Signal peptide (Syn-Coll, DSM/Pentapharm/Symrise) that mimics TGF-β (transforming growth factor-beta), stimulating collagen synthesis in fibroblasts via the TGF-β signaling pathway. Palmitoyl lipidation enhances stratum corneum penetration. Used in supramolecular collagen nanoparticle formulations combining lactoferrin, recombinant human collagen, and this peptide.
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restrictions. No pre-market approval required under MoCRA for cosmetic peptides.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Palmitoyl Tripeptide-5.
Calculate MoS for your specific formulation with the MoS Calculator.
Editorial summary
Preliminary editorial summary for Palmitoyl Tripeptide-5 — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
proprietary-symrise
syn-coll
signal-peptide
tgf-beta-mimetic
collagen-stimulator
Frequently Asked Questions
Is Palmitoyl Tripeptide-5 allowed in the EU?
Palmitoyl Tripeptide-5 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Palmitoyl Tripeptide-5 do in cosmetics?
Palmitoyl Tripeptide-5 functions as: Signal peptide (Syn-Coll, DSM/Pentapharm/Symrise) that mimics TGF-β (transforming growth factor-beta), stimulating collagen synthesis in fibroblasts via the TGF-β signaling pathway. Palmitoyl lipidation enhances stratum corneum penetration. Used in supramolecular collagen nanoparticle formulations combining lactoferrin, recombinant human collagen, and this peptide.. It is classified as a Active Ingredient in our database. CAS number: None.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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