Regulatory Status
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Safety Data
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Expert Verdict
Palmitoyl Tripeptide-5 (Syn-Coll) is a TGF-β mimetic signal peptide driving collagen synthesis in fibroblasts, with clinical evidence showing 21.57% nasolabial fold length reduction in supramolecular nanoparticle formulations and synergistic anti-aging benefits in multi-active combinations.
Regulatory Flags
Frequently Asked Questions
Is Palmitoyl Tripeptide-5 safe in cosmetics?
Palmitoyl Tripeptide-5 (Syn-Coll) is a TGF-β mimetic signal peptide driving collagen synthesis in fibroblasts, with clinical evidence showing 21.57% nasolabial fold length reduction in supramolecular nanoparticle formulations and synergistic anti-aging benefits in multi-active combinations. The EU classifies Palmitoyl Tripeptide-5 as "permitted". Safety rating: EXCELLENT.
Is Palmitoyl Tripeptide-5 allowed in the EU?
Palmitoyl Tripeptide-5 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Palmitoyl Tripeptide-5 do in cosmetics?
Palmitoyl Tripeptide-5 functions as: Signal peptide (Syn-Coll, DSM/Pentapharm/Symrise) that mimics TGF-β (transforming growth factor-beta), stimulating collagen synthesis in fibroblasts via the TGF-β signaling pathway. Palmitoyl lipidation enhances stratum corneum penetration. Used in supramolecular collagen nanoparticle formulations combining lactoferrin, recombinant human collagen, and this peptide.. It is classified as a Active Ingredient in our database. CAS number: None.
What is the Margin of Safety for Palmitoyl Tripeptide-5?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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