Regulatory Status
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Safety Data
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Expert Verdict
Excellent corticosteroid-mimetic anti-inflammatory without steroid side effects. Stearyl glycyrrhetinate (licorice root-derived) inhibits 11β-hydroxysteroid dehydrogenase (11β-HSD), amplifying local cortisol activity at the site of application, and inhibits phospholipase A2, blocking arachidonic acid release from membrane phospholipids. This dual mechanism delivers corticosteroid-mimetic anti-inflammatory potency without skin-thinning, telangiectasia, and adrenal suppression risks of topical steroids. The stearyl ester form provides superior skin penetration vs water-soluble glycyrrhizin. Effective at 0.2–1% in leave-on formulations. Not restricted in EU or US.
Regulatory Flags
Frequently Asked Questions
Is Stearyl Glycyrrhetinate safe in cosmetics?
Excellent corticosteroid-mimetic anti-inflammatory without steroid side effects. Stearyl glycyrrhetinate (licorice root-derived) inhibits 11β-hydroxysteroid dehydrogenase (11β-HSD), amplifying local cortisol activity at the site of application, and inhibits phospholipase A2, blocking arachidonic acid release from membrane phospholipids. This dual mechanism delivers corticosteroid-mimetic anti-inflammatory potency without skin-thinning, telangiectasia, and adrenal suppression risks of topical steroids. The stearyl ester form provides superior skin penetration vs water-soluble glycyrrhizin. Effective at 0.2–1% in leave-on formulations. Not restricted in EU or US. The EU classifies Stearyl Glycyrrhetinate as "permitted". Safety rating: EXCELLENT.
Is Stearyl Glycyrrhetinate allowed in the EU?
Stearyl Glycyrrhetinate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Stearyl Glycyrrhetinate do in cosmetics?
Stearyl Glycyrrhetinate functions as: anti-inflammatory, skin-conditioning. It is classified as a Active Ingredient in our database. CAS number: 13832-70-7.
What is the Margin of Safety for Stearyl Glycyrrhetinate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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