Tazarotene

INCI: TAZAROTENE

CAS Number
118292-40-3
Function
skin-conditioning, anti-aging
Safety Rating
MODERATE

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status restricted
EU Max Conc. Prescription only
๐Ÿ‡บ๐Ÿ‡ธ US Status restricted
US Notes Rx; 0.05-0.1%; most potent topical retinoid; highest irritation risk

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
high
Sensitization
high

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Most potent prescription topical retinoid with RAR-beta/gamma selectivity; highest irritation and teratogenicity risk in retinoid class, reserved for treatment-resistant photoaging or acne under medical supervision.

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Concern Level: High

Regulatory Flags

rx-only teratogen high-irritation rar-selective

Frequently Asked Questions

Is Tazarotene safe in cosmetics?

Most potent prescription topical retinoid with RAR-beta/gamma selectivity; highest irritation and teratogenicity risk in retinoid class, reserved for treatment-resistant photoaging or acne under medical supervision. The EU classifies Tazarotene as "restricted". Safety rating: MODERATE.

Is Tazarotene allowed in the EU?

Tazarotene EU regulatory status: restricted. Maximum allowed concentration: Prescription only. This is based on EU Regulation 1223/2009 and its amendments.

What does Tazarotene do in cosmetics?

Tazarotene functions as: skin-conditioning, anti-aging. It is classified as a Active Ingredient in our database. CAS number: 118292-40-3.

What is the Margin of Safety for Tazarotene?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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