Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Zinc Gluconate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOEL | 3000 ppm | oral | mouse | oral | REACH |
| NOAEL | 2 mg/kg bw/day | 2011 | rat | other | REACH |
| NOEL | 3000 ppm | oral | rat | oral | REACH |
| NOEL | 3000 ppm | oral | - | oral | REACH |
| NOEL | 3000 ppm | oral | - | oral | REACH |
Dermal Penetration Profile
Skin absorption and penetration characteristics of Zinc Gluconate, relevant to systemic exposure and MoS calculations.
Source: Cosmetic Science
Expert Verdict
Zinc gluconate is an essential micronutrient for hair follicle function. It inhibits 5ฮฑ-reductase (reducing DHT at the follicle), regulates hair follicle keratinocyte proliferation, and supports multiple enzyme systems involved in follicle cycling. Zinc deficiency is associated with alopecia areata and diffuse hair loss; deficiency-driven hair loss responds to zinc repletion. Topical cosmetic zinc gluconate is used in scalp formulations with a GOOD safety profile at cosmetic concentrations.
Regulatory Flags
Frequently Asked Questions
Is Zinc Gluconate safe in cosmetics?
Zinc gluconate is an essential micronutrient for hair follicle function. It inhibits 5ฮฑ-reductase (reducing DHT at the follicle), regulates hair follicle keratinocyte proliferation, and supports multiple enzyme systems involved in follicle cycling. Zinc deficiency is associated with alopecia areata and diffuse hair loss; deficiency-driven hair loss responds to zinc repletion. Topical cosmetic zinc gluconate is used in scalp formulations with a GOOD safety profile at cosmetic concentrations. The EU classifies Zinc Gluconate as "permitted". Safety rating: GOOD. 5 toxicological study endpoint(s) are available in our database.
Is Zinc Gluconate allowed in the EU?
Zinc Gluconate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Zinc Gluconate do in cosmetics?
Zinc Gluconate functions as: 5-alpha-reductase inhibitor; hair-follicle cycle regulator; anti-seborrheic; antioxidant; scalp micronutrient. It is classified as a Active Ingredient in our database. CAS number: 4468-02-4.
What is the Margin of Safety for Zinc Gluconate?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Zinc Gluconate?
The NOAEL (No Observed Adverse Effect Level) for Zinc Gluconate is 3000 ppm based on a oral study via oral route in mouse. A total of 5 study endpoints are available. Source: REACH.
Compliance Tools
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Related Ingredients
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