Excellent Active Ingredient SCCS/CIR Reviewed Sensitization Data

CALENDULA OFFICINALIS FLOWER EXTRACT

CAS Number
84776-23-8
Function
skin-conditioning, anti-inflammatory, soothing
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes CIR: calendula extract safe in cosmetics at present practices of use; anti-inflammatory properties beneficial for barrier-compromised lip skin; particularly valuable in lip care for chemotherapy patients (mucositis) and sensitive lip conditions; no FDA restrictions

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
moderate
Sensitization
low

Calculate MoS for your specific formulation with the MoS Calculator.

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir 7 January 2001
Verdict: unknown

Sensitization Profile

Contact sensitization data for CALENDULA OFFICINALIS FLOWER EXTRACT based on clinical patch test studies and IFRA standards.

Sensitization Rate
low
Allergen Class
botanical
EU Allergen Listed
no
Patch Test Positive Rate
0.5%
Cross-reactivity Group
compositae-group
Reaction Type
contact-dermatitis

Source: IVDK; ESSCA; NACDG

Expert Verdict

Anti-inflammatory botanical extract rich in flavonoids and triterpenoids, particularly valuable in lip care for barrier-compromised conditions including mucositis from chemotherapy. CIR confirms safety. Very low sensitization risk except for Asteraceae-sensitized individuals. Excellent choice for sensitive, compromised, and supportive-care lip formulations.

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Concern Level: Low

Regulatory Flags

cir-approved cosmos-eligible natural vegan lip-safe oral-safe anti-inflammatory soothing mucositis-care chemotherapy-lip-care asteraceae-caution ecocert-eligible eu_children_restricted

Frequently Asked Questions

Is CALENDULA OFFICINALIS FLOWER EXTRACT safe in cosmetics?

Anti-inflammatory botanical extract rich in flavonoids and triterpenoids, particularly valuable in lip care for barrier-compromised conditions including mucositis from chemotherapy. CIR confirms safety. Very low sensitization risk except for Asteraceae-sensitized individuals. Excellent choice for sensitive, compromised, and supportive-care lip formulations. The EU classifies CALENDULA OFFICINALIS FLOWER EXTRACT as "permitted". Safety rating: EXCELLENT. This ingredient has been reviewed by cir.

Is CALENDULA OFFICINALIS FLOWER EXTRACT allowed in the EU?

CALENDULA OFFICINALIS FLOWER EXTRACT EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does CALENDULA OFFICINALIS FLOWER EXTRACT do in cosmetics?

CALENDULA OFFICINALIS FLOWER EXTRACT functions as: skin-conditioning, anti-inflammatory, soothing. It is classified as a Active Ingredient in our database. CAS number: 84776-23-8.

What is the Margin of Safety for CALENDULA OFFICINALIS FLOWER EXTRACT?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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