Excellent Active Ingredient

Hydroxyectoin

INCI: HYDROXYECTOIN

CAS Number
81210-65-3
Function
Hydroxylated analogue of ectoin; compatible solute from extremophilic bacteria. Enhanced thermostability versus ectoin. Mechanism: stronger kosmotropic hydration shell formation providing superior protection at elevated temperatures, UV stress, osmotic extremes, and inflammatory challenges. Anti-inflammatory and barrier support. Used in heat-stress formulations and premium longevity skincare.
Safety Rating
EXCELLENT

Regulatory Status

๐Ÿ‡ช๐Ÿ‡บ EU Status permitted
๐Ÿ‡บ๐Ÿ‡ธ US Status permitted
US Notes Permitted without restriction. Biotechnology-derived via fermentation. Premium longevity active with superior thermostability versus ectoin. MoCRA safety substantiation required.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
not established
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Hydroxyectoin is a thermostable derivative of ectoin with evidence-backed positioning in longevity skincare, offering enhanced protection against heat stress, UV damage, and environmental stressors with excellent tolerability and no documented sensitization risk.

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Concern Level: None

Regulatory Flags

longevity-skincare biotech-derived barrier-function anti-inflammatory uv-protection thermostable pollution-protection

Frequently Asked Questions

Is Hydroxyectoin safe in cosmetics?

Hydroxyectoin is a thermostable derivative of ectoin with evidence-backed positioning in longevity skincare, offering enhanced protection against heat stress, UV damage, and environmental stressors with excellent tolerability and no documented sensitization risk. The EU classifies Hydroxyectoin as "permitted". Safety rating: EXCELLENT.

Is Hydroxyectoin allowed in the EU?

Hydroxyectoin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Hydroxyectoin do in cosmetics?

Hydroxyectoin functions as: Hydroxylated analogue of ectoin; compatible solute from extremophilic bacteria. Enhanced thermostability versus ectoin. Mechanism: stronger kosmotropic hydration shell formation providing superior protection at elevated temperatures, UV stress, osmotic extremes, and inflammatory challenges. Anti-inflammatory and barrier support. Used in heat-stress formulations and premium longevity skincare.. It is classified as a Active Ingredient in our database. CAS number: 81210-65-3.

What is the Margin of Safety for Hydroxyectoin?

not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

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