Excellent Cosmetic Ingredient NOAEL Data GHS Classified

Isoamyl Acetate

INCI: ISOAMYL ACETATE

CAS Number
123-92-2
Function
Fragrance, Solvent
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR safe as used (1988, reaffirmed 2022); FEMA GRAS

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
high
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Isoamyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL 1000 mg/kg bw/day oral rat oral REACH
NOAEL 250 mg/kg bw/day oral rat oral REACH
NOAEL 1250 mg/kg bw/day oral rat oral REACH
NOEL 100 mg/kg bw/day oral rat oral REACH
NOAEL 1476.9 mg/kg bw/day oral - oral REACH
NOAEL 369.22 mg/kg bw/day oral - oral REACH
NOAEL 1846.11 mg/kg bw/day oral - oral REACH
NOEL 147.69 mg/kg bw/day oral - oral REACH
NOEL 100 mg/kg bw/day oral rat oral REACH
NOAEL 1250 mg/kg bw/day oral rat oral REACH

GHS Hazard Classification

Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.

Short-term Exposure Effects
The vapour is irritating to the eyes and respiratory tract. Exposure to high concentrations of vapour could cause unconsciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.

Expert Verdict

Isoamyl Acetate is a Cramer Class I fragrance ester with excellent safety margins (>72,000x), no sensitization concerns, and confirmed safe use history.

⚠️
Concern Level: None

Regulatory Flags

epa_safer_alternative ifra_fragrance fda_food_additive

Frequently Asked Questions

Is Isoamyl Acetate safe in cosmetics?

Isoamyl Acetate is a Cramer Class I fragrance ester with excellent safety margins (>72,000x), no sensitization concerns, and confirmed safe use history. The EU classifies Isoamyl Acetate as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.

Is Isoamyl Acetate allowed in the EU?

Isoamyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Isoamyl Acetate do in cosmetics?

Isoamyl Acetate functions as: Fragrance, Solvent. It is classified as a Cosmetic Ingredient in our database. CAS number: 123-92-2.

What is the Margin of Safety for Isoamyl Acetate?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

What is the NOAEL for Isoamyl Acetate?

The NOAEL (No Observed Adverse Effect Level) for Isoamyl Acetate is 1000 mg/kg bw/day based on a oral study via oral route in rat. A total of 10 study endpoints are available. Source: REACH.

Compliance Tools

Check Isoamyl Acetate compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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