Is Isoamyl Acetate safe in cosmetics?
Isoamyl Acetate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Isoamyl Acetate
Also known as: 4-02-00-00157, Amyl acetate, common, BRN 1744750, EINECS 204-662-3, FEMA No. 2055 (+14 more)
INCI: ISOAMYL ACETATE
Isoamyl Acetate (CAS 123-92-2) is a cosmetic cosmetic ingredient functioning as Fragrance, Solvent. NOAEL 250 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 123-92-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Isoamyl Acetate is classified GHS Danger (H226, H316, H320, H335, H336, H372) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance, Solvent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
3-methylbutyl acetate
InChIKey
MLFHJEHSLIIPHL-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR safe as used (1988, reaffirmed 2022); FEMA GRAS
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isoamyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The vapour is irritating to the eyes and respiratory tract. Exposure to high concentrations of vapour could cause unconsciousness.
Long-term Exposure Effects
The substance defats the skin, which may cause dryness or cracking.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its vapour and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Isoamyl Acetate across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
5184 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [37] Kligman AM (1973): Report to RIFM, 27 August, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5184 | - | - |
| HRIPT | - | 0 | 21259.84 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
ICSC Safety Card
0356
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
Overexposure to isoamyl acetate may cause irritation of the eyes, nose, and throat. | at 300 ppm in air vapor is noticeably irritating to ... eyes.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
43
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ISOAMYL ACETATE | 1996 | 0-3 mg/kg bw (1979) | No safety concern at current levels of intake when used as a flavouring agent. The 1979 group ADI of 0-3 mg/kg bw for isoamyl acetate and isoamyl butyrate, expressed as isoamyl alcohol, was maintained at the forty-sixth meeting (1996). | TRS 868-JECFA 46/23 | See TRS 868-JECFA 46/68
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
No specific technical function
Solvent
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Isoamyl Acetate.
Regulatory Flags
epa_safer_alternative
ifra_fragrance
fda_food_additive
Known Synonyms
4-02-00-00157
Amyl acetate, common
BRN 1744750
EINECS 204-662-3
FEMA No. 2055
FEMA Number 2055
In Commercial practice amyl invariably means isoamyl, unless it is prefaced by the n- for normal
beta-Methylbutyl acetate
2-Methylbutyl ethanoate
Isoamylester kyseliny octove
UNII-Z135787824
3-Methyl butyl ester acetic acid
3-Methyl-1-butanol, acetate
3-Methyl-1-butanyl acetate
3-methyl-1-butanol acetate
3-methyl-but-1-yl acetate
CH3C(O)O(CH2)2CH(CH3)2
FEMA 2055
Isoamylacetat
Chemical Function
Solvent
No specific technical function
Flavouring and nutrient
Fragrance
Regulatory Lists
air; detected; emissions; Personal care
air; Cleaning products and household care - air freshener; detected; emissions
inert_ingredient; non_food_use; Pesticides
consumer_product; detected
Australia; Food and drug - smoking-related products
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL42013
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ISOAMYL ACETATE
ADI
0-3 mg/kg bw (1979) mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Isoamyl Acetate allowed in the EU?
Isoamyl Acetate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isoamyl Acetate do in cosmetics?
Isoamyl Acetate functions as: Fragrance, Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 123-92-2.
Is Isoamyl Acetate used outside cosmetics?
Isoamyl Acetate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Isoamyl Acetate have different safety status in cosmetics vs industrial chemicals?
Isoamyl Acetate is classified GHS Danger (H226, H316, H320, H335, H336, H372) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Isoamyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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