Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
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Dermal Penetration Profile
Skin absorption and penetration characteristics of Phytosphingosine, relevant to systemic exposure and MoS calculations.
Source: J Lipid Res 2003
Expert Verdict
Phytosphingosine is an endogenous ceramide precursor that is bioconverted to ceramides in the skin's biosynthesis pathway, addressing ceramide depletion in aging skin while providing anti-inflammatory benefits. No regulatory restrictions in EU or US with excellent safety profile and tolerability.
Regulatory Flags
Frequently Asked Questions
Is Phytosphingosine safe in cosmetics?
Phytosphingosine is an endogenous ceramide precursor that is bioconverted to ceramides in the skin's biosynthesis pathway, addressing ceramide depletion in aging skin while providing anti-inflammatory benefits. No regulatory restrictions in EU or US with excellent safety profile and tolerability. The EU classifies Phytosphingosine as "permitted". Safety rating: EXCELLENT.
Is Phytosphingosine allowed in the EU?
Phytosphingosine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phytosphingosine do in cosmetics?
Phytosphingosine functions as: Skin-conditioning agent, ceramide precursor, anti-inflammatory sphingoid base; bioconverted to ceramides in skin; broad-spectrum antimicrobial; reduces inflammation. It is classified as a Active Ingredient in our database. CAS number: 554-62-1.
What is the Margin of Safety for Phytosphingosine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
Compliance Tools
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Related Ingredients
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