Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
9 study endpoints found for Thiamine HCl. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 300 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| NOAEL | 7.5 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| NOAEL | 10000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 50 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 300 mg/kg bw/day | oral | rat | Multigeneration Reproductive | COSMOS_DB |
| dose_tested | 7.5 mg/kg bw/day | oral | rat | Reproductive | COSMOS_DB |
| dose_tested | 10000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
Expert Verdict
Minimal cosmetic relevance compared to niacinamide and panthenol — included in vitamin B complex formulations primarily for completeness or synergy claims. Safe by analogy with extensive oral vitamin safety, best positioned as a minor antioxidant support ingredient in multi-vitamin or skin-energy concept formulations.
Regulatory Flags
Frequently Asked Questions
Is Thiamine HCl safe in cosmetics?
Minimal cosmetic relevance compared to niacinamide and panthenol — included in vitamin B complex formulations primarily for completeness or synergy claims. Safe by analogy with extensive oral vitamin safety, best positioned as a minor antioxidant support ingredient in multi-vitamin or skin-energy concept formulations. The EU classifies Thiamine HCl as "permitted". Safety rating: GOOD. 9 toxicological study endpoint(s) are available in our database.
Is Thiamine HCl allowed in the EU?
Thiamine HCl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Thiamine HCl do in cosmetics?
Thiamine HCl functions as: Antioxidant support; skin energy co-factor; skin conditioning. It is classified as a Active Ingredient in our database. CAS number: 67-03-8.
What is the Margin of Safety for Thiamine HCl?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Thiamine HCl?
The NOAEL (No Observed Adverse Effect Level) for Thiamine HCl is 50 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 9 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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