Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for Calcium Pantothenate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 2000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 5 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 400 mg/kg bw/day | oral | monkey | Chronic | COSMOS_DB |
| NOAEL | 50 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | 20 mg/kg bw/day | oral | mouse | Chronic | COSMOS_DB |
| NOAEL | 5 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 2000 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| dose_tested | 5 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| dose_tested | 400 mg/kg bw/day | oral | monkey | Chronic | COSMOS_DB |
| dose_tested | 20 mg/kg bw/day | oral | mouse | Chronic | COSMOS_DB |
Expert Verdict
Excellent dual-function barrier repair and skin-conditioning active delivering provitamin B5 and calcium ion for keratinocyte differentiation and epidermal maturation. Ideal for barrier-repair, sensitive skin, post-procedure, and wound-healing formulations with outstanding safety profile. Use at 0.5–2% in moisturisers, serums, and barrier creams.
Regulatory Flags
Frequently Asked Questions
Is Calcium Pantothenate safe in cosmetics?
Excellent dual-function barrier repair and skin-conditioning active delivering provitamin B5 and calcium ion for keratinocyte differentiation and epidermal maturation. Ideal for barrier-repair, sensitive skin, post-procedure, and wound-healing formulations with outstanding safety profile. Use at 0.5–2% in moisturisers, serums, and barrier creams. The EU classifies Calcium Pantothenate as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
Is Calcium Pantothenate allowed in the EU?
Calcium Pantothenate EU regulatory status: permitted. Maximum allowed concentration: 0.5–2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Pantothenate do in cosmetics?
Calcium Pantothenate functions as: Provitamin B5 (pantothenic acid) calcium salt; barrier repair active; skin-conditioning; supports keratinocyte differentiation via calcium gradient signaling; humectant; promotes wound healing and skin elasticity. It is classified as a Active Ingredient in our database. CAS number: 137-08-6.
What is the Margin of Safety for Calcium Pantothenate?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Calcium Pantothenate?
The NOAEL (No Observed Adverse Effect Level) for Calcium Pantothenate is 2000 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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