Is Calcium Pantothenate safe in cosmetics?
Calcium Pantothenate has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
EXCELLENT
Active Ingredient
Calcium Pantothenate
Also known as: beta-Alanine, N-((2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, calcium salt (2:1), .beta.-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, calcium salt (2:1), EC No.: 205-278-9, Calpan, D-Pantothenic acid hemicalcium salt (+15 more)
INCI: CALCIUM PANTOTHENATE
Calcium Pantothenate (CAS 137-08-6) is a cosmetic active ingredient functioning as Provitamin B5 (pantothenic acid) calcium salt; barrier repair active;. EU Regulation 1223/2009 status: permitted, max 0.5–2%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
Function
Provitamin B5 (pantothenic acid) calcium salt; barrier repair active; skin-conditioning; supports keratinocyte differentiation via calcium gradient signaling; humectant; promotes wound healing and skin elasticity
Editorial assessment
EXCELLENT
Preliminary editorial note — not a computed safety verdict.
Chemistry & Identifiers
IUPAC Name
calcium bis(3-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]propanoate)
InChIKey
FAPWYRCQGJNNSJ-UBKPKTQASA-L
Regulatory Status
EU EU Status
permitted
EU Max Conc.
0.5–2%
US US Status
permitted
US Notes
No FDA restriction; used as cosmetic and OTC drug ingredient (wound-healing, skin-conditioning). CIR has not identified safety concerns at cosmetic concentrations.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Calcium Pantothenate.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
2 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =10000 mg/kg | Mouse | oral | - | ChemIDplus |
| LD50 | >10000 mg/kg | Rat | oral | - | ChemIDplus |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Flavouring and nutrient
Pharmaceutical
Softener and conditioner
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Editorial summary
Preliminary editorial summary for Calcium Pantothenate — not a computed safety verdict. See the sourced toxicological data above.
Regulatory Flags
provitamin-b5
barrier-repair
keratinocyte-support
calcium-gradient
skin-conditioning
wound-healing
hair-care
gentle
well-tolerated
epa_safer_alternative
fda_food_additive
Known Synonyms
beta-Alanine, N-((2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-, calcium salt (2:1)
.beta.-Alanine, N-[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]-, calcium salt (2:1)
EC No.: 205-278-9
Calpan
D-Pantothenic acid hemicalcium salt
Pancal
Panthothenic acid hemicalcium salt
calcium pantothenate , D-form
N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine calcium salt (2:1)
Bis(pantothenato)calcium
Ca-HOPA
Calcium D(+)-N-(alpha,gamma-dihydroxy-beta,beta-dimethylbutyryl)-beta-alaninate
Calcium N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-beta-alanine (1:2), (R)-
Calcium panthothenate
Calcium pantothenate (2:1)
D-Calcium pantothenate calcium chloride double salt
Cris Pan
N-(2,4-Dihydroxy-3,3-dimethylbutyryl)-beta-alanine calcium
EINECS 205-278-9
Pantothenic acid, calcium salt
Chemical Function
Anti-static agent
Softener and conditioner
Pharmaceutical
Regulatory Lists
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
CALCIUM PANTOTHENATE
ChEMBL ID
CHEMBL1901349
Max Phase
2
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Vitamin B5 - Calcium D-Pantothenate
Food Category
vitamins_minerals
Frequently Asked Questions
Is Calcium Pantothenate allowed in the EU?
Calcium Pantothenate EU regulatory status: permitted. Maximum allowed concentration: 0.5–2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Calcium Pantothenate do in cosmetics?
Calcium Pantothenate functions as: Provitamin B5 (pantothenic acid) calcium salt; barrier repair active; skin-conditioning; supports keratinocyte differentiation via calcium gradient signaling; humectant; promotes wound healing and skin elasticity. It is classified as a Active Ingredient in our database. CAS number: 137-08-6.
Is Calcium Pantothenate used outside cosmetics?
Calcium Pantothenate also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Calcium Pantothenate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acetyl Tetrapeptide-5
EXCELLENT
Same category
Anti-edema peptide for periorbital ar...
Activated Charcoal
EXCELLENT
Same category
Adsorbent; skin cleanser; pore-cleans...
Adenosine
EXCELLENT
Same category
Skin-conditioning agent, anti-aging, ...
Allantoin
EXCELLENT
Same category
Skin conditioner, keratolytic, anti-i...
Alpha-Glucan Oligosaccharide
EXCELLENT
Same category
prebiotic, skin-conditioning
Ascophyllum Nodosum Extract
EXCELLENT
Same category
Skin Brightening, Tyrosinase Inhibito...
1-Methylhydantoin-2-imide (Creatinine)
EXCELLENT
Similar safety
Skin conditioning (skin brightening/l...
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
EXCELLENT
Similar safety
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
EXCELLENT
Similar safety
Fragrance (rich woody, orris/iris roo...
2-Hydroxypropylcarbamato Amodimethicone
EXCELLENT
Similar safety
Hair conditioning; modified aminosili...
2-O-Ethyl Ascorbic Acid
EXCELLENT
Similar safety
Softener and conditioner
3 O Ethyl Ascorbic Acid
EXCELLENT
Similar safety
Antioxidant; tyrosinase inhibitor; me...
2,4-Diaminophenol HCl
POOR
Chemical family
Oxidative hair dye coupler
2-Heptylcyclopentanone
GOOD
Chemical family
Fragrance ingredient (cyclopentanone ...
2-Methylbutanol
GOOD
Chemical family
Fragrance ingredient; solvent
Is Calcium Pantothenate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Calcium Pantothenate in your formulation.