Linalool
INCI: LINALOOL
Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
3 study endpoints found for Linalool. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1500 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
| dose_tested | 1000 mg/kg bw/day | oral | rat | Developmental | COSMOS_DB |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Sensitization Profile
Contact sensitization data for Linalool based on clinical patch test studies and IFRA standards.
Source: ESSCA/NACDG
Dermal Penetration Profile
Skin absorption and penetration characteristics of Linalool, relevant to systemic exposure and MoS calculations.
Source: SCCS/1459/11, IFRA
Expert Verdict
Widespread natural fragrance constituent with low risk in fresh unoxidized state; oxidation transforms it into a potent allergen. Antioxidant stabilization, nitrogen blanketing during filling, and minimized headspace are essential GMP measures. Mandatory EU allergen declaration above thresholds and protection from oxidation throughout shelf life required.
Regulatory Flags
Frequently Asked Questions
Is Linalool safe in cosmetics?
Widespread natural fragrance constituent with low risk in fresh unoxidized state; oxidation transforms it into a potent allergen. Antioxidant stabilization, nitrogen blanketing during filling, and minimized headspace are essential GMP measures. Mandatory EU allergen declaration above thresholds and protection from oxidation throughout shelf life required. The EU classifies Linalool as "restricted". Safety rating: MODERATE. 3 toxicological study endpoint(s) are available in our database.
Is Linalool allowed in the EU?
Linalool EU regulatory status: restricted. Maximum allowed concentration: Mandatory individual label declaration above 10 ppm in leave-on products, 100 ppm in rinse-off products (EU 26 allergen list). IFRA 51st Amendment imposes stricter limits on linalool hydroperoxide content in formulations.. This is based on EU Regulation 1223/2009 and its amendments.
What does Linalool do in cosmetics?
Linalool functions as: fragrance; skin-conditioning. It is classified as a Fragrance in our database. CAS number: 78-70-6.
What is the Margin of Safety for Linalool?
not established The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Linalool?
The NOAEL (No Observed Adverse Effect Level) for Linalool is 1500 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 3 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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