Regulatory Status
For full compliance data across 55 jurisdictions, use the Substance Compliance tool.
Safety Data
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Glycine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 10000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 1600 mg/kg bw/day | oral | rat | Carcinogenicity | COSMOS_DB |
| LOAEL | 1500 mg/kg bw/day | 2400 | rat | other | REACH |
| LOAEL | 1561 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=600 mg/kg bw/day | 2011 | rat | other | REACH |
| NOAEL | >=1000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=2000 mg/kg bw/day | oral | rat | oral | REACH |
| NOAEL | >=1000 mg/kg bw/day | oral | - | oral | REACH |
Dermal Penetration Profile
Skin absorption and penetration characteristics of Glycine, relevant to systemic exposure and MoS calculations.
Source: CIR
Expert Verdict
Glycine is structurally essential for collagen stability and a well-tolerated cosmetic active with CIR-assessed safety and confirmed GRAS status. No restrictions or safety concerns at cosmetic use levels.
Regulatory Flags
Frequently Asked Questions
Is Glycine safe in cosmetics?
Glycine is structurally essential for collagen stability and a well-tolerated cosmetic active with CIR-assessed safety and confirmed GRAS status. No restrictions or safety concerns at cosmetic use levels. The EU classifies Glycine as "permitted". Safety rating: EXCELLENT. 8 toxicological study endpoint(s) are available in our database.
Is Glycine allowed in the EU?
Glycine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glycine do in cosmetics?
Glycine functions as: Most abundant amino acid in collagen (every third residue in Gly-X-Y triplet). Improves visible signs of aging, enhances moisture retention, promotes collagen production, strengthens skin, and supports repair and regeneration.. It is classified as a Active Ingredient in our database. CAS number: 56-40-6.
What is the Margin of Safety for Glycine?
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
What is the NOAEL for Glycine?
The NOAEL (No Observed Adverse Effect Level) for Glycine is 10000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 8 study endpoints are available. Source: COSMOS_DB.
Compliance Tools
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Related Ingredients
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