Is Linalyl Acetate safe in cosmetics?
Linalyl Acetate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted.
Linalyl Acetate
Also known as: 1,6-Octadien-3-ol, 3,7-dimethyl-, acetate, 3,7-Dimethyl-1,6-octadien-3-ol acetate, EINECS 204-116-4, EINECS 254-806-4, FEMA No. 2636 (+4 more)
INCI: LINALYL ACETATE
Linalyl Acetate (CAS 115-95-7) is a cosmetic fragrance functioning as fragrance. NOAEL 117 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 0.001% (leave-on) / 0.01% (rinse-off) - declarable allergen under EU 2023/1545; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 115-95-7 →
Auto-generated CPSR Part A draft with source citations
Function
fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3,7-dimethylocta-1,6-dien-3-yl acetate
InChIKey
UWKAYLJWKGQEPM-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
EU Max Conc.
0.001% (leave-on) / 0.01% (rinse-off) - declarable allergen under EU 2023/1545
US US Status
permitted
US Notes
Permitted; RIFM-assessed
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Linalyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Hazard Statements
Combustible liquid Causes eye irritation Toxic to aquatic life
Short-term Exposure Effects
The substance is mildly irritating to the eyes.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Linalyl Acetate across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
6480 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [269] RIFM (1974): RIFM report number 1801, May 31, unpublished.
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 99 | 0 | 2362 | 2362 | non-sensitizer |
| HMT | - | 0 | 6480 | - | - |
| HMT | - | 0 | 6750 | - | - |
| HMT | - | 0 | 7448.28 | - | - |
| HMT | - | 0 | 13500 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Additional Ingredient Properties
2 property records from structured ingredient metadata.
ecotoxicity
{"biodegradable": "yes", "biodegradation_days": "14-28", "bioaccumulative": "no", "aquatic_toxicity_level": "low", "coral_reef_safe": "yes", "marine_toxicity": "low-moderate toxicity", "freshwater_toxicity": "moderate at high conc", "endocrine_disruptor": "no", "persistent_organic_pollutant": "no", "microplastic": "no", "nano_particle": "no", "hawaii_banned": "no", "eu_restricted_environmental": "…
fragrance_ifra
{"cas_number": "115-95-7", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.14", "ifra_max_use_level_category_4_pct": "2.2", "ifra_max_use_level_category_7_pct": "0.32", "ifra_max_use_level_category_11_pct": "0.065", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_po…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
ICSC Safety Card
1716
Source: WHO/JECFA
Skin Eye Respiratory Irritation
A severe skin irritant. | Linalyl acetate (100%) appeared to be severely irritating to rabbit skin and moderately irritating to the skin of the guinea pig. In a test with miniature swines, application of 0.05 g linalyl acetate under a patch for 48 hours /caused/ no irritation ... .
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
359
Source: WHO/JECFA
JECFA Evaluation
3,7-DIMETHYLOCTA-1,6-DIEN-3-YL ACETATE | 1998 | 0-0.5 mg/kg bw (1979) | No safety concern at current levels of intake when used as a flavouring agent. The 1979 group ADI of 0-0.5 mg/kg bw for citral, geranyl acetate, citronellol, linalool, and linalyl acetate, expressed as citral, was maintained at the fifty-first (TRS 891/90, 1998) and sixty-first (TRS for JECFA 61 in press) meetings. | TRS 891-J
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Linalyl Acetate.
Regulatory Flags
allergen-eu
sensitization-risk
oxidation-sensitive
ifra-restricted
eu-labelling-required
eu-2023-1545-newly-listed
hydroperoxide-forming
epa_safer_alternative
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Linalyl Acetate by CAS number or substance name.
Studies
21
Lowest NOAEL
117 mg/kg bw/day
Highest NOAEL
750 mg/kg bw/day
ECHA
Known Synonyms
1,6-Octadien-3-ol, 3,7-dimethyl-, acetate
3,7-Dimethyl-1,6-octadien-3-ol acetate
EINECS 204-116-4
EINECS 254-806-4
FEMA No. 2636
Licareol acetate
Linalol acetate
Lynalyl acetate
UNII-5K47SSQ51G
Chemical Function
Fragrance
Regulatory Lists
Cleaning products and household care - air freshener; Europe
air; detected; emissions; Europe; Vehicle - car interior
detected; Europe; Vehicle - car interior
detected; Europe; Personal care - sexual wellness
detected; Europe; Personal care - sexual wellness
inert_ingredient; non_food_use; Pesticides
air; detected; emissions; Europe; Vehicle - car interior
active_ingredient; Europe; Pesticides
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
LINALYL ACETATE
ChEMBL ID
CHEMBL502773
Frequently Asked Questions
Is Linalyl Acetate allowed in the EU?
Linalyl Acetate EU regulatory status: restricted. Maximum allowed concentration: 0.001% (leave-on) / 0.01% (rinse-off) - declarable allergen under EU 2023/1545. This is based on EU Regulation 1223/2009 and its amendments.
What does Linalyl Acetate do in cosmetics?
Linalyl Acetate functions as: fragrance. It is classified as a Fragrance in our database. CAS number: 115-95-7.
Is Linalyl Acetate classified as hazardous under GHS?
Linalyl Acetate carries a GHS signal word of "WARNING". Hazard statements: Combustible liquid Causes eye irritation Toxic to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Linalyl Acetate used outside cosmetics?
Linalyl Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Linalyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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