Excellent Active Ingredient

PANTOTHENIC ACID

CAS Number
79-83-4
Function
Hair conditioning; skin conditioning; coenzyme A precursor; epidermal function support
Safety Rating
EXCELLENT

Regulatory Status

🇪🇺 EU Status permitted
🇺🇸 US Status permitted
US Notes CIR Expert Panel assessed in same 1987 review as panthenol and derivatives — concluded safe in cosmetics in present practices of use and concentration. Reaffirmed after 15-year review. Coenzyme A constituent; essential for epithelial function.

For full compliance data across 55 jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety (MoS)
adequate
Dermal Absorption
low
Sensitization
none

Calculate MoS for your specific formulation with the MoS Calculator.

Expert Verdict

Pantothenic acid is the active metabolite of panthenol in skin, with CIR-confirmed safety in cosmetics. Less commonly used directly due to superior skin penetration of panthenol, which enzymatically converts to this compound in situ. Suitable for hair and skin conditioning with excellent safety profile and no sensitization concerns.

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Concern Level: None

Regulatory Flags

hair-conditioning skin-conditioning coenzyme-a-precursor cir-reaffirmed panthenol-conversion-product water-soluble epa_safer_alternative

Frequently Asked Questions

Is PANTOTHENIC ACID safe in cosmetics?

Pantothenic acid is the active metabolite of panthenol in skin, with CIR-confirmed safety in cosmetics. Less commonly used directly due to superior skin penetration of panthenol, which enzymatically converts to this compound in situ. Suitable for hair and skin conditioning with excellent safety profile and no sensitization concerns. The EU classifies PANTOTHENIC ACID as "permitted". Safety rating: EXCELLENT.

Is PANTOTHENIC ACID allowed in the EU?

PANTOTHENIC ACID EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does PANTOTHENIC ACID do in cosmetics?

PANTOTHENIC ACID functions as: Hair conditioning; skin conditioning; coenzyme A precursor; epidermal function support. It is classified as a Active Ingredient in our database. CAS number: 79-83-4.

What is the Margin of Safety for PANTOTHENIC ACID?

adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.

Compliance Tools

Check PANTOTHENIC ACID compliance across multiple jurisdictions:

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Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
 🧪
Substance Compliance
Check compliance across 55 jurisdictions
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
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Heavy Metal Limits
Compare limits across jurisdictions

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