Regulatory Cluster 4680 ingredients

Cosmetic Ingredients with CIR Expert Panel Conclusions

The Cosmetic Ingredient Review (CIR) is a voluntary U.S. industry-funded expert panel that assesses the safety of cosmetic ingredients and publishes conclusions in the International Journal of Toxicology. CIR conclusions fall into several categories: "Safe as used" (no concentration restriction), "Safe with qualifications" (subject to specific conditions such as max concentration or product type), "Insufficient data to support safety", and "Unsafe". CIR operates independently of the FDA but its conclusions are widely referenced by cosmetic brands, regulators, and formulators globally. This cluster lists cosmetic ingredients with published CIR conclusions, showing the most recent assessment verdict and final report reference.

Functional Categories
Skin Conditioning Ingredients Humectants in Cosmetics Emollient Ingredients in Cosmetics Antioxidants in Cosmetics Surfactants in Cosmetics Emulsifiers in Cosmetics Fragrance Ingredients in Cosmetics Cosmetic Colorants Cosmetic Preservatives UV Filters & Sunscreen Ingredients Hair Conditioning Ingredients Rheology Modifiers & Thickeners Active Cosmetic Ingredients Plant Extracts & Botanical Ingredients
Regulatory Clusters
Cosmetic Ingredients Flagged as Endocrine Disruptors Cosmetic Ingredients Listed Under California Proposition 65 Cosmetic Ingredients with SCCS Safety Opinions Cosmetic Ingredients with CIR Expert Panel Conclusions Cosmetic Ingredients with GHS Hazard Classification Cosmetic Ingredients with NOAEL Toxicological Data Cosmetic Ingredients Banned or Restricted Globally Cosmetic Ingredients with Sensitization Data Cosmetic Ingredients with Dermal Absorption Data Cosmetic Ingredients Restricted Under EU Regulation 1223/2009
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #
Ingredient Safety CIR Conclusion
1,10-Decanediol Good Safe as Used
1,2,4-Trihydroxybenzene Poor Safe with Qualifications
1,4-Butanediol Poor Insufficient Data
1,4-Butanediol/Succinic Acid/Adipic Acid/HDI Copolymer Good Safe as Used
1,5-Pentanediol Good Safe as Used
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate Moderate Safe as Used
1-Naphthol Moderate Safe as Used
10-Hydroxydecanoic Acid Good Safe with Qualifications
10-Hydroxystearic Acid Good Safe with Qualifications
2,3-Butanediol Moderate Insufficient Data
2,3-Naphthalenediol Poor Use Not Supported
2,4-Diaminophenol Poor Safe with Qualifications
2,4-Diaminophenol HCl Poor Safe with Qualifications
2,4-Diaminophenoxyethanol HCl Moderate Safe as Used
2,4-Diaminophenoxyethanol Sulfate Moderate Safe as Used
2-Amino-4-Hydroxyethylaminoanisole Moderate Safe with Qualifications
2-Amino-4-Hydroxyethylaminoanisole Sulfate Moderate Safe with Qualifications
2-Amino-4-Nitrophenol Moderate Safe as Used
2-Amino-6-Chloro-4-Nitrophenol Moderate Safe with Qualifications
2-BROMO-2-NITROPROPANE-1,3-DIOL Moderate Safe with Qualifications
2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) Moderate Safe with Qualifications
2-Chloro-P-Phenylenediamine Poor Safe as Used
2-Chloro-P-Phenylenediamine Sulfate Poor Safe as Used
2-Ethoxyethanol Poor Unsafe
2-Methyl-5-Hydroxyethylaminophenol Moderate Safe as Used
2-Methylresorcinol Moderate Safe as Used
2-Methylresorcinol ⭐ (Most extensively assessed) Moderate Safe as Used
2-Nitro-P-Phenylenediamine Poor Safe as Used
4-Amino-2-Hydroxytoluene Moderate Safe as Used
4-Amino-2-Nitrophenol ⚠️ Poor Use Not Supported
4-Amino-3-Nitrophenol Moderate Safe as Used
4-Chlororesorcinol Moderate Safe as Used
4-Hydroxybenzoic Acid Excellent Safe with Qualifications
4-Hydroxypropylamino-3-Nitrophenol Good Safe as Used
4-Nitro-M-Phenylenediamine Poor Use Not Supported
4-Nitro-O-Phenylenediamine Moderate Safe as Used
5-Amino-4-Chloro-o-Cresol Moderate Safe with Qualifications
5-Amino-4-Chloro-o-Cresol HCl Moderate Safe with Qualifications
5-Amino-6-Chloro-o-Cresol Moderate Safe as Used
5-Bromo-5-Nitro-1,3-Dioxane Moderate Safe with Qualifications
6-Amino-M-Cresol Poor Safe as Used
6-Amino-O-Cresol Poor Safe with Qualifications
ACETYL CYSTEINE Good Safe with Qualifications
ACETYL GLUCOSAMINE Good Safe with Qualifications
ACRYLAMIDE Moderate Safe with Qualifications
ACRYLATES/PERFLUOROHEXYLETHYL METHACRYLATE COPOLYMER Good Use Not Supported
AHNFELTIOPSIS CONCINNA EXTRACT Good Insufficient Data
ALLYL METHACRYLATE/GLYCOL DIMETHACRYATE CROSSPOLYMER Good Safe with Qualifications
ALOE ARBORESCENS LEAF EXTRACT Good Use Not Supported
ALOE BARBADENSIS FLOWER EXTRACT Good Safe with Qualifications
ALOE BARBADENSIS LEAF Good Safe with Qualifications
AMINOETHYL PROPANEDIOL Good Safe as Used
AMMONIUM POLYACRYLATE Good Safe with Qualifications
AMP-Acrylates Copolymer Good Safe with Qualifications
AMP-Acrylates/C1-18 Alkyl Acrylate/C1-8 Alkyl Acrylamide Copolymer Good Safe as Used
ANTHEMIS NOBILIS FLOWER EXTRACT Good Safe with Qualifications
ANTHEMIS NOBILIS FLOWER WATER Good Safe with Qualifications
ARACHIDONIC ACID Good Use Not Supported
ASPARAGOPSIS ARMATA EXTRACT Good Insufficient Data
Abyssinian Oil Good Safe as Used
Acacia Catechu Gum Moderate Use Not Supported
Acacia Concinna Fruit Extract Moderate Use Not Supported
Acacia Concinna Fruit Powder Moderate Use Not Supported
Acacia Dealbata Leaf Extract Moderate Use Not Supported
Acacia Decurrens Extract Moderate Use Not Supported
Acacia Farnesiana Extract Moderate Use Not Supported
Acacia Farnesiana Flower/Stem Extract Poor Use Not Supported
Acacia Farnesiana Gum Poor Use Not Supported
Acacia Senegal Flower/Stem Extract Poor Use Not Supported
Acetamide MEA Moderate Safe with Qualifications
Acetic Acid Good Safe as Used
Acetic Acid — Deep Research Profile Good Safe as Used
Acetic/Linoleic/Palmitic Triglyceride Excellent Safe as Used
Acetyl Arginine Good Safe with Qualifications
Acetyl Carnitine Good Safe with Qualifications
Acetyl Carnitine HCl Good Safe with Qualifications
Acetyl Glutamic Acid Good Safe with Qualifications
Acetyl Glutamine Good Safe with Qualifications
Acetyl Histidine Moderate Safe with Qualifications
Acetyl Methionine Excellent Safe with Qualifications
Acetyl Proline Excellent Safe with Qualifications
Acetyl Tributyl Citrate Good Safe as Used
Acetyl Triethyl Citrate Excellent Safe as Used
Acetyl Trihexyl Citrate Excellent Safe as Used
Acetyl Tyrosine Good Safe with Qualifications
Acetylated Lanolin Good Safe as Used
Acetylated Lanolin Alcohol Good Safe as Used
Achillea Millefolium Extract Good Safe with Qualifications
Achillea Millefolium Extract Good Safe with Qualifications
Achillea Millefolium Flower Extract Good Safe with Qualifications
Achillea Millefolium Flower/Leaf/Stem Extract Good Safe with Qualifications
Acid Orange 3 Poor Safe with Qualifications
Acrylamide/Ammonium Acrylate Copolymer Moderate Safe as Used
Acrylamide/Sodium Acrylate Copolymer Moderate Safe as Used
Acrylamide/Sodium Acryloyldimethyltaurate Copolymer Good Safe as Used
Acrylamide/Sodium Acryloyldimethyltaurate Copolymer Moderate Safe as Used
Acrylamide/Sodium Acryloyldimethyltaurate/Acrylic Acid Copolymer Moderate Safe as Used
Acrylamidopropyltrimonium Chloride/Acrylamide Copolymer Good Safe with Qualifications
Acrylamidopropyltrimonium Chloride/Acrylates Copolymer Good Safe with Qualifications
Acrylates Copolymer Good Safe with Qualifications
Acrylates Crosspolymer Good Safe with Qualifications
Acrylates Crosspolymer-3 Excellent Safe with Qualifications
Acrylates Crosspolymer-4 Excellent Safe with Qualifications
Acrylates/Acrylamide Copolymer Good Safe as Used
Acrylates/Ammonium Methacrylate Copolymer Good Safe with Qualifications
Acrylates/Beheneth-25 Methacrylate Copolymer Good Safe with Qualifications
Acrylates/Bis-Hydroxypropyl Dimethicone Crosspolymer Good Safe as Used
Acrylates/C10-30 Alkyl Acrylate Crosspolymer Good Safe with Qualifications
Acrylates/C10-30 Alkyl Methacrylate Copolymer Good Safe with Qualifications
Acrylates/C12-22 Alkyl Methacrylate Copolymer Good Safe with Qualifications
Acrylates/C5-8 Alkyl Acrylate Copolymer Good Safe with Qualifications
Acrylates/Ceteth-20 Methacrylate Copolymer Good Safe with Qualifications
Acrylates/Dimethiconol Acrylate Copolymer Good Safe as Used
Acrylates/Ethylhexyl Acrylate Copolymer Good Safe with Qualifications
Acrylates/Ethylhexyl Acrylate Crosspolymer Good Safe with Qualifications
Acrylates/Ethylhexyl Acrylate/Glycidyl Methacrylate Crosspolymer Moderate Safe with Qualifications
Acrylates/Ethylhexyl Acrylate/Styrene Copolymer Good Safe as Used
Acrylates/Hydroxyesters Acrylates Copolymer Good Safe with Qualifications
Acrylates/Hydroxyethyl Acrylate/Lauryl Acrylate Copolymer Good Safe with Qualifications
Acrylates/Hydroxyethyl Acrylate/Methoxyethyl Acrylate Copolymer Good Safe with Qualifications
Acrylates/Laureth-25 Methacrylate Copolymer Good Safe with Qualifications
Acrylates/Lauryl Methacrylate Copolymer Good Safe with Qualifications
Acrylates/Lauryl Methacrylate/Tridecyl Methacrylate Crosspolymer Good Safe with Qualifications
Acrylates/Methacrylamide Copolymer Good Safe as Used
Acrylates/Methoxy PEG-15 Methacrylate Copolymer Good Safe with Qualifications
Acrylates/Methoxy PEG-23 Methacrylate Copolymer Good Safe with Qualifications
Acrylates/Methoxy PEG-4 Methacrylate Copolymer Good Safe with Qualifications
Acrylates/Methoxy PEG-90 Methacrylate Crosspolymer Good Safe with Qualifications
Acrylates/Octylacrylamide Copolymer Good Safe as Used
Acrylates/PEG-4 Dimethacrylate Crosspolymer Good Safe with Qualifications
Acrylates/Palmeth-25 Acrylate Copolymer Good Safe with Qualifications
Acrylates/Perfluorohexylethyl Methacrylate Copolymer ⚠️ Moderate Use Not Supported
Acrylates/Steareth-20 Methacrylate Copolymer Good Safe with Qualifications
Acrylates/Steareth-20 Methacrylate Crosspolymer Good Safe with Qualifications
Acrylates/Steareth-50 Acrylate Copolymer Good Safe with Qualifications
Acrylates/Stearyl Methacrylate Copolymer Good Safe with Qualifications
Acrylates/Stearyl Methacrylate/VP Copolymer Moderate Safe as Used
Acrylates/T-Butylacrylamide Copolymer Good Safe as Used
Acrylates/VA Copolymer Good Safe with Qualifications
Acrylates/VA Crosspolymer Good Safe with Qualifications
Acrylates/VP Copolymer Good Safe as Used
Acrylates/Vinyl Isodecanoate Crosspolymer Good Safe with Qualifications
Acrylates/Vinyl Neodecanoate Crosspolymer Excellent Safe with Qualifications
Acrylic Acid/C12-22 Alkyl Acrylate Copolymer Good Safe with Qualifications
Acrylic Acid/Phosphorylcholine Glycol Acrylate Crosspolymer Moderate Safe as Used
Acrylic Acid/Stearyl Acrylate Copolymer Moderate Safe with Qualifications
Acrylic Acid/VP Crosspolymer Moderate Safe as Used
Acryloyloxypropyl Polysilsesquioxane Good Safe as Used
Activated Charcoal Excellent Safe as Used
Adansonia Digitata Seed Oil PEG-8 Esters Good Safe with Qualifications
Adansonia Digitata Seed Oil Polyglyceryl-6 Esters Good Safe with Qualifications
Adenosine Excellent Safe as Used
Adenosine Phosphate Good Safe as Used
Adenosine Triphosphate Good Safe as Used
Adenosine Triphosphate (ATP) Good Safe as Used
Adipic Acid Excellent Safe as Used
Adipic Acid Dihydrazide Poor Insufficient Data
Adipic Acid/Neopentyl Glycol/Trimellitic Anhydride Copolymer Poor Safe with Qualifications
Agar Excellent Safe as Used
Agarose Good Safe as Used
Agarum Cribrosum Extract Moderate Safe as Used
Alaria Esculenta Extract Good Safe as Used
Alcohol Denat. SD Alcohol 1 Good Use Not Supported
Alcohol Denat. SD Alcohol 23-A Good Use Not Supported
Alcohol Denat. SD Alcohol 46 Good Use Not Supported
Aldioxa Moderate Use Not Supported
Algae Exopolysaccharides Good Safe as Used
Algae-Derived Biopolymers Moderate Safe as Used
Algin Excellent Safe as Used
Algin (Alginic Acid) Good Safe as Used
Alginic Acid Excellent Safe as Used
Alkyl Benzoate Excellent Safe as Used
Allyl Methacrylate/Glycol Dimethacrylate Crosspolymer Good Safe with Qualifications
Allyl Methacrylates Crosspolymer Excellent Safe with Qualifications
Almond Oil PEG-6 Esters Good Safe with Qualifications
Almond Oil PEG-8 Esters Excellent Safe with Qualifications
Almond Oil Propylene Glycol Esters Good Safe with Qualifications
Almondamide DEA Moderate Safe with Qualifications
Almondamidopropyl Dimethylamine Moderate Safe with Qualifications
Aloe Andongensis Leaf Extract Moderate Use Not Supported
Aloe Andongensis Leaf Juice Moderate Use Not Supported
Aloe Arborescens Leaf Juice Moderate Use Not Supported
Aloe Arborescens Leaf Protoplasts Moderate Use Not Supported
Aloe Barbadensis Leaf Extract Good Safe with Qualifications
Aloe Barbadensis Leaf Juice Good Safe with Qualifications
Aloe Barbadensis Leaf Juice Good Safe with Qualifications
Aloe Barbadensis Leaf Polysaccharides Excellent Safe with Qualifications
Aloe Barbadensis Leaf Water Excellent Safe with Qualifications
Aloe Ferox Leaf Extract Moderate Use Not Supported
Aloe Ferox Leaf Juice Moderate Use Not Supported
Aloe Ferox Leaf Juice Extract Moderate Use Not Supported
Aloe Vera (Aloe Barbadensis Leaf Juice) Good Safe with Qualifications
Alumina Good Safe as Used
Aluminum Calcium Sodium Silicate Good Safe as Used
Aluminum Citrate Good Safe as Used
Aluminum Dilinoleate Good Safe with Qualifications
Aluminum Dimyristate Good Safe as Used
Aluminum Distearate Excellent Safe with Qualifications
Aluminum Hydroxide Good Safe as Used
Aluminum Isostearate Good Safe with Qualifications
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