Regulatory Cluster 200 ingredients

Cosmetic Ingredients with Sensitization Data

Skin sensitization is a two-stage adverse immune response to a substance: induction (first exposure, asymptomatic) and elicitation (subsequent exposure, visible allergic contact dermatitis). Under EU Regulation 1223/2009 and the 7th Amendment Ban on Animal Testing, sensitization assessment for cosmetic ingredients uses non-animal methods: the Direct Peptide Reactivity Assay (DPRA, OECD TG 442C), KeratinoSens (OECD TG 442D), h-CLAT (OECD TG 442E), and the Local Lymph Node Assay (LLNA, OECD TG 429 — still permitted for non-cosmetic substances). Human Repeat Insult Patch Tests (HRIPTs) provide clinical confirmation and the NESIL (No Expected Sensitisation Induction Level). The SARA ICE master database integrates data across all five methods per substance. This cluster lists cosmetic ingredients with sensitization data from any of these sources.

Functional Categories
Skin Conditioning Ingredients Humectants in Cosmetics Emollient Ingredients in Cosmetics Antioxidants in Cosmetics Surfactants in Cosmetics Emulsifiers in Cosmetics Fragrance Ingredients in Cosmetics Cosmetic Colorants Cosmetic Preservatives UV Filters & Sunscreen Ingredients Hair Conditioning Ingredients Rheology Modifiers & Thickeners Active Cosmetic Ingredients Plant Extracts & Botanical Ingredients
Regulatory Clusters
Cosmetic Ingredients Flagged as Endocrine Disruptors Cosmetic Ingredients Listed Under California Proposition 65 Cosmetic Ingredients with SCCS Safety Opinions Cosmetic Ingredients with CIR Expert Panel Conclusions Cosmetic Ingredients with GHS Hazard Classification Cosmetic Ingredients with NOAEL Toxicological Data Cosmetic Ingredients Banned or Restricted Globally Cosmetic Ingredients with Sensitization Data Cosmetic Ingredients with Dermal Absorption Data Cosmetic Ingredients Restricted Under EU Regulation 1223/2009
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z #
Ingredient Safety Sensitization
1,3-BIS-(2,4-DIAMINOPHENOXY) PROPANE HCL Good 1B
1,5-Naphthalenediol Moderate 1B
1,6-HEXAMETHYLENE DIISOCYANATE Good Sensitizer
1,6-HEXAMETHYLENE DIISOCYANATE Good -
1,6-Hexamethylene Diisocyanate (HDI) Poor Sensitizer
1,6-Hexamethylene Diisocyanate (HDI) Poor -
1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate Moderate 1B
1-Naphthol Moderate low
2,3-DIHYDRO-2,2,6-TRIMETHYLBENZALDEHYDE Good 1B
2,3-Dihydro-2,2,6-trimethylbenzaldehyde (Safranal) Good 1B
2,4-DIMETHYLBENZYLACETATE Good 1B
2,4-Diaminophenoxyethanol HCl Moderate 1B
2,4-Dimethylbenzyl acetate Good 1B
2,6-DIAMINOPYRIDINE Good low
2,6-Diaminopyridine ⚠️ Poor low
2,6-Dihydroxyethylaminotoluene Good 1B
2,6-Dimethoxy-3,5-Pyridinediamine HCl Moderate -
2,6-Dimethylheptanol Good 1B
2,7-Naphthalenediol Moderate 1B
2-Amino-3-Hydroxypyridine Good low
2-Amino-4-Hydroxyethylaminoanisole Moderate low
2-Amino-6-Chloro-4-Nitrophenol Moderate low
2-BROMO-2-NITROPROPANE-1,3-DIOL Moderate 1B
2-Bromo-2-Nitropropane-1,3-Diol (Bronopol) Moderate 1B
2-Decenal Moderate 1B
2-Ethyl-2-(3-Methylbut-2-Enyl)Hex-3-Enol Moderate 1B
2-Heptylcyclopentanone Good 1B
2-Hexylidenecyclopentanone ⚠️ Moderate 1B
2-Hydroxyethyl Acrylate Moderate 1A
2-Melozol Acetate Good 1B
2-Methoxy-p-Cresol Moderate 1B
2-Methyl-5-Hydroxyethylaminophenol Moderate low
2-Methyldodecanal Moderate 1B
2-Methylresorcinol Moderate 1B
2-Methylresorcinol ⭐ (Most extensively assessed) Moderate 1B
2-Nitro-P-Phenylenediamine Poor low
2-Nonyn-1-Al Dimethylacetal Good 1B
3-(P-Cumenyl)-2-Methylpropionaldehyde Moderate 1B
3-Isopentenyl Acetate Good 1B
3-METHYL-5-(2,2,3-TRIMETHYL-3-CYCLOPENTENYL)PENT-4-EN-2-OL Good low
3-METHYL-5-PROPYL-2-CYCLOHEXENONE Good 1B
3-Methyl-5-Propyl-2-Cyclohexenone (Celery Ketone) Good 1B
3-Nitro-P-Hydroxyethylaminophenol Moderate -
3-Propylidenephthalide Good low
4-Amino-2-Hydroxytoluene Moderate low
4-Amino-3-Nitrophenol Moderate 1A
4-Amino-M-Cresol Moderate 1A
4-Chlororesorcinol Moderate low
4-Hydroxybenzoic Acid Excellent 1B
4-Hydroxypropylamino-3-Nitrophenol Good 1B
4-Methyl-1-Oxaspiroundecene Good 1B
4-Nitro-O-Phenylenediamine Moderate low
4-TERPINEOL Good 1B
4-TERT-BUTYLDIHYDROCINNAMALDEHYDE Moderate 1B
4-Terpineol (Terpinen-4-ol) Good 1B
4-Tert-Butyldihydrocinnamaldehyde (Bourgeonal) Moderate moderate
5-Amino-6-Chloro-o-Cresol Moderate low
5-Bromo-5-Nitro-1,3-Dioxane Moderate low
5-Melozol Acetate (Melozol Acetate) Good 1B
6-Hydroxyindole Good low
ANILINE Moderate 1B
AVOBENZONE (BUTYL METHOXYDIBENZOYLMETHANE) Good inconclusive
Abietic Acid Moderate 1B
Acetaldehyde Phenethyl Propyl Acetal Good low
Acetylcedrene Moderate 1B
Achillea Millefolium Extract Good low
Achillea Millefolium Extract Good low
Acid Black 1 Poor low
Acid Blue 9 Excellent low
Albumen Moderate -
Alcohol Good -
Alcohol Denat Moderate -
Allyl Heptanoate Good 1B
Allyl Heptine Carbonate Moderate 1B
Allyl Phenoxyacetate Moderate 1B
Allyl Phenylacetate Moderate 1B
Aloe Barbadensis Leaf Juice Good low
Aloe Barbadensis Leaf Juice Good low
Aloe Vera (Aloe Barbadensis Leaf Juice) Good low
Alpha,3,3-Trimethylcyclohexylmethyl Acetate Good 1B
Alpha-Damascone Moderate 1B
Alpha-Isomethyl Ionone Good low
Alpha-Phellandrene Moderate 1B
Alpha-Terpinene Moderate -
Aminoethylethanolamine Moderate -
Ammonium Persulfate Poor -
Amyl Cinnamal Moderate low
Amyl Salicylate Good low
Amylcinnamyl Alcohol Moderate low
Amylvinylcarbinyl Acetate Good 1B
Aniba Rosaeodora Amazonica Wood Oil Good low
Aniba Rosaeodora Wood Oil Good low
Anise Alcohol Good low
Anisyl Acetate Good 1B
Anthemis Nobilis Flower Oil Good low
Arctium Lappa Root Extract Good low
Arnica Montana Flower Extract Moderate moderate
Artemisia Absinthium Extract Moderate low
Atranol Poor low
Atranol - BANNED Poor low
Avobenzone Good inconclusive
Avocado Oil (Persea Gratissima Oil) Good low
BENZALDEHYDE Good low
BENZOPHENONE-3 Moderate 1B
BORNANEDIONE Good -
BUTYLPHENYL METHYLPROPIONAL Moderate moderate
Balsam Copaiba Good low
Basic Blue 99 Moderate low
Basic Brown 16 Poor low
Basic Brown 17 Good low
Basic Yellow 57 Good low
Benzalkonium Chloride Moderate low
Benzisothiazolinone Moderate very-high
Benzoic Acid Good low
Benzonitrile Poor 1B
Benzophenone-3 (Oxybenzone) Moderate 1B
Benzoyl Peroxide Regulatory & Good 1A
Benzyl Acetate Excellent low
Benzyl Acetone Good 1B
Benzyl Alcohol Moderate low
Benzyl Benzoate Moderate low
Benzyl Cinnamate Moderate low
Benzyl Formate Good low
Benzyl Salicylate Moderate low
Benzylhemiformal Moderate low
Benzylparaben Poor low
Bornanedione (Camphorquinone) Moderate -
Boswellia Carterii Oil Good low
Bronopol Moderate low
Burdock Oil Good low
Butyl Acrylate Good 1B
Butyl Benzyl Phthalate Poor 1B
Butyl Benzyl Phthalate (BBP) Poor 1B
Butyl Isobutyrate Good 1B
Butyl Methoxydibenzoylmethane Good inconclusive
Butylparaben Moderate low
Butylphenyl Methylpropional (Lilial) Poor moderate
Butyrospermum Parkii Butter Excellent low
CALENDULA OFFICINALIS FLOWER EXTRACT Excellent low
CAMELLIA SINENSIS EXTRACT Good -
CAMELLIA SINENSIS EXTRACT Good Sensitizer
CAMELLIA SINENSIS EXTRACT Good Non-sensitizer
CAMELLIA SINENSIS SEED EXTRACT Good -
CAMELLIA SINENSIS SEED EXTRACT Good Sensitizer
CAMELLIA SINENSIS SEED EXTRACT Good Non-sensitizer
CINNAMAL Moderate moderate
CINNAMOMUM CAMPHORA OIL Good low
CINNAMOMUM ZEYLANICUM BARK OIL Good low
CIS-6-NON-6-ENAL Good 1B
COLLOIDAL SULFUR Good -
COPAIFERA OFFICINALIS RESIN Good low
Calcium Paraben Moderate low
Camellia Sinensis Leaf Extract Excellent -
Camellia Sinensis Leaf Extract Excellent Sensitizer
Camellia Sinensis Leaf Extract Excellent Non-sensitizer
Camellia Sinensis Leaf Water Good -
Camellia Sinensis Leaf Water Good Sensitizer
Camellia Sinensis Leaf Water Good Non-sensitizer
Camphor Moderate low
Cananga Odorata Leaf Oil Moderate -
Cananga Odorata Leaf Oil Moderate Sensitizer
Canarium Luzonicum Gum Oil Good low
Capixyl (Acetyl Tetrapeptide-3, Trifolium Pratense Extract) Good inconclusive
Caprylic Acid Good 1B
Caprylyl Glycol Good low
Captan Moderate 1B
Carvacrol Moderate low
Carvone Moderate low
Cedrenol Moderate 1B
Cedrol Good low
Cedrus Atlantica Bark Oil Moderate low
Centaurea Cyanus Flower Extract Moderate low
Cetearyl Alcohol Excellent low
Cetearyl Glucoside Excellent low
Cetrimonium Bromide Good low
Cetyl Alcohol Excellent low
Chamomile Extract (Matricaria Chamomilla Extract) Good low
Chloramine T Good 1B
Chlorhexidine Digluconate Moderate low
Chlorine Dioxide Poor -
Chloroacetamide Poor low
Chloroatranol Poor low
Chloroatranol - BANNED Poor low
Chloroxylenol Good low
Chloroxylenol (PCMX) Good low
Chlorphenesin Good low
Chrysanthemum Indicum Extract Moderate low
Cinnamal (Cinnamaldehyde) Moderate moderate
Cinnamaldehyde Moderate low
Cinnamaldehyde Dimethyl Acetal Moderate 1B
Cinnamaldehyde/Methyl Anthranilate Schiff Base Moderate 1B
Cinnamic Acid Good low
Cinnamomum Cassia Leaf Oil Poor low
Cinnamyl Alcohol Moderate moderate
Citral Moderate moderate
Citral-Acid Isomerized Moderate moderate
Citrol Moderate moderate
Citronellal Moderate 1B
Citronellol Moderate low
Citrus Limon Peel Oil Moderate low
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